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  1. Pancreatic adenocarcinoma (PDAC) is well known for its rapid distant metastasis and local destructive behavior. Loss of Krüppel-like factor 10 (KLF10) contributes to distant migration of PDAC. The role of KLF1...

    Authors: Yi-Chih Tsai, Kung Hung Cheng, Shih Sheng Jiang, John R. Hawse, Shun En Chuang, Su Liang Chen, Tze-Sing Huang and Hui-Ju Ch’ang
    Citation: Journal of Biomedical Science 2023 30:39
    Content type: Research Published on:

  2. The intestinal epithelial barrier is the interface for interaction between gut microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key player in the colonic microbiota that reside...

    Authors: Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N. Harris and Qiaozhu Su
    Citation: Journal of Biomedical Science 2023 30:38
    Content type: Research Published on:

  3. We investigated the presence of heteroresistance against both tigecycline and colistin in Acinetobacter baumannii and then evaluated the effectiveness of combined antibiotic treatment given the existence of discr...

    Authors: Jeongwoo Jo, Ki Tae Kwon and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2023 30:37
    Content type: Research Published on:

  4. Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment a...

    Authors: Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson and James R. Connor
    Citation: Journal of Biomedical Science 2023 30:36
    Content type: Research Published on:

  5. Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. However, the commercial production of cancer-specific T cells is often hampered by laborious cell cul...

    Authors: Yi-Jou Chen, Michael Chen, Tian-Lu Cheng, Yi-Shan Tsai, Chang-Hung Wang, Che-Yi Chen, Tung-Yun Wu, Shey-Cherng Tzou, Kai-Hung Wang, Jing-Jy Cheng, An-Pei Kao, Shyr-Yi Lin and Kuo-Hsiang Chuang
    Citation: Journal of Biomedical Science 2023 30:35
    Content type: Research Published on:

  6. Clustered Regularly Interspaced Short Palindromic repeats (CRISPR)-Cas systems rapidly raised from a bacterial genetic curiosity to the most popular tool for genetic modifications which revolutionized the stud...

    Authors: Rima Zein-Eddine, Guislaine Refrégier, Jorge Cervantes and Noemí Kaoru Yokobori
    Citation: Journal of Biomedical Science 2023 30:34
    Content type: Review Published on:

  7. The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved ...

    Authors: Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau and Ruey-Bing Yang
    Citation: Journal of Biomedical Science 2023 30:33
    Content type: Review Published on:

  8. Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as...

    Authors: Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung and David K. Ann
    Citation: Journal of Biomedical Science 2023 30:32
    Content type: Research Published on:

  9. Klebsiella pneumoniae capsular types K1, K2, K5, K20, K54, and K57 are prevalent hypervirulent types associated with community infections, and worrisomely, hypervirulent strains that acquired drug resistance have...

    Authors: Jia-Wen Wu, Jin-Town Wang, Tzu-Lung Lin, Ya-Zhu Liu, Lii-Tzu Wu and Yi-Jiun Pan
    Citation: Journal of Biomedical Science 2023 30:31
    Content type: Research Published on:

  10. The coronavirus disease 2019 (COVID-19) pandemic has impacted human lifestyles around the world, causing huge distress in terms of public health systems, emergency response capacity and economic development. T...

    Authors: Jaung-Geng Lin, Guan-Jhong Huang and Yi-Chang Su
    Citation: Journal of Biomedical Science 2023 30:30
    Content type: Review Published on:

  11. Gram-positive (G+) bacterial infection is a great burden to both healthcare and community medical resources. As a result of the increasing prevalence of multidrug-resistant G+ bacteria such as methicillin-resista...

    Authors: He Liu, Zhen Hu, Mengyang Li, Yi Yang, Shuguang Lu and Xiancai Rao
    Citation: Journal of Biomedical Science 2023 30:29
    Content type: Review Published on:

  12. Ingestion of alcoholic beverages is a known trigger of migraine attacks. However, whether and how ethanol exerts its pro-migraine action remains poorly known. Ethanol stimulates the transient receptor potentia...

    Authors: Lorenzo Landini, Daniel Souza Monteiro de Araujo, Martina Chieca, Gaetano De Siena, Elisa Bellantoni, Pierangelo Geppetti, Romina Nassini and Francesco De Logu
    Citation: Journal of Biomedical Science 2023 30:28
    Content type: Research Published on:

  13. Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein 43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron disease. Recent studies have shown that both C-t...

    Authors: Yu-Ling Tseng, Po-Chao Lu, Chi-Chang Lee, Ruei-Yu He, Yung-An Huang, Yin-Chen Tseng, Ting-Jen Rachel Cheng, Joseph Jen-Tse Huang and Jim-Min Fang
    Citation: Journal of Biomedical Science 2023 30:27
    Content type: Research Published on:

  14. Although mRNA dysregulation can induce changes in mesenchymal stem cell (MSC) homeostasis, the mechanisms by which post-transcriptional regulation influences MSC differentiation potential remain understudied. ...

    Authors: Dong Suk Yoon, Yoorim Choi, Kyoung-Mi Lee, Eun Ae Ko, Eun-Ji Kim, Kwang Hwan Park and Jin Woo Lee
    Citation: Journal of Biomedical Science 2023 30:26
    Content type: Research Published on:

  15. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a clinically critical pathogen that causes severe infection. Due to improper antibiotic administration, the prevalence of CRKP infection has been increasing co...

    Authors: Yu-Ming Zhang, Mei-Fen Tsao, Ching-Yu Chang, Kuan-Ting Lin, Joseph Jordan Keller and Hsiu-Chen Lin
    Citation: Journal of Biomedical Science 2023 30:25
    Content type: Research Published on:

  16. Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased...

    Authors: Lisa J. Ioannidis, Stephanie I. Studniberg, Emily M. Eriksson, Suhendro Suwarto, Dionisius Denis, Yang Liao, Wei Shi, Alexandra L. Garnham, R. Tedjo Sasmono and Diana S. Hansen
    Citation: Journal of Biomedical Science 2023 30:24
    Content type: Research Published on:

  17. The tumor microenvironment (TME) has a central role in the oncogenesis of osteosarcomas. The composition of the TME is essential for the interaction between tumor and immune cells. The aim of this study was to...

    Authors: Changwu Wu, Siming Gong, Yingjuan Duan, Chao Deng, Sonja Kallendrusch, Laura Berninghausen, Georg Osterhoff and Nikolas Schopow
    Citation: Journal of Biomedical Science 2023 30:23
    Content type: Research Published on:

  18. The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS). In this s...

    Authors: Suyeon Park, Hyunkeun Kim and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2023 30:22
    Content type: Research Published on:

  19. The microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus representing both biological prerequisite and therapeutic vulnerability in ...

    Authors: Zhengquan Wu, Bernd Uhl, Olivier Gires and Christoph A. Reichel
    Citation: Journal of Biomedical Science 2023 30:21
    Content type: Research Published on:

  20. Although immune checkpoint blockade (ICB) therapy has brought survival benefits to patients with specific cancer types, most of cancer patients remain refractory to the ICB therapy, which is largely attributed...

    Authors: Ning Ma, Rong Hua, Yang Yang, Zhi-Chao Liu, Jie Pan, Bo-Yao Yu, Yi-Feng Sun, Dong Xie, Yan Wang and Zhi-Gang Li
    Citation: Journal of Biomedical Science 2023 30:20
    Content type: Research Published on:

  21. Lactobacilli are essential microbiota that maintain a healthy, balanced vaginal environment. Vaginitis is a common infection in women during their reproductive years. Many factors are associated with vaginitis...

    Authors: Ameda Abdullah Bnfaga, Kai Wei Lee, Leslie Thian Lung Than and Syafinaz Amin-Nordin
    Citation: Journal of Biomedical Science 2023 30:19
    Content type: Research Published on:

  22. Reactivation of Epstein Barr virus (EBV) leads to modulation of the viral and cellular epitranscriptome. N6-methyladenosine (m6A) modification is a type of RNA modification that regulates metabolism of mRNAs. Pre...

    Authors: Dipayan Bose, Xiang Lin, Le Gao, Zhi Wei, Yonggang Pei and Erle S. Robertson
    Citation: Journal of Biomedical Science 2023 30:18
    Content type: Research Published on:

  23. E26 transformation-specific (ETS) transcription variant 5 (ETV5), also known as ETS-related molecule (ERM), exerts versatile functions in normal physiological processes, including branching morphogenesis, neur...

    Authors: Yi Wei, Shenqi Han, Jingyuan Wen, Jingyu Liao, Junnan Liang, Jingjing Yu, Xiaoping Chen, Shuai Xiang, Zhao Huang and Bixiang Zhang
    Citation: Journal of Biomedical Science 2023 30:17
    Content type: Review Published on:

  24. Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs al...

    Authors: Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang and Nigel H. Greig
    Citation: Journal of Biomedical Science 2023 30:16
    Content type: Research Published on:

  25. Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children under 5 years of age, characterized by typical manifestations such as oral herpes and rashes on the hands and feet. These s...

    Authors: Peiyu Zhu, Wangquan Ji, Dong Li, Zijie Li, Yu Chen, Bowen Dai, Shujie Han, Shuaiyin Chen, Yuefei Jin and Guangcai Duan
    Citation: Journal of Biomedical Science 2023 30:15
    Content type: Review Published on:

  26. Influenza is one of the most important viral infections globally. Viral RNA-dependent RNA polymerase (RdRp) consists of the PA, PB1, and PB2 subunits, and the amino acid residues of each subunit are highly con...

    Authors: Mei-Lin Yang, Yi-Cheng Chen, Chung-Teng Wang, Hao-Earn Chong, Nai-Hui Chung, Chia-Hsing Leu, Fu-Tong Liu, Michael M. C. Lai, Pin Ling, Chao-Liang Wu and Ai-Li Shiau
    Citation: Journal of Biomedical Science 2023 30:14
    Content type: Research Published on:

  27. Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how RRBP1 regulates blood...

    Authors: Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu…
    Citation: Journal of Biomedical Science 2023 30:13
    Content type: Research Published on:

  28. Zika virus (ZIKV) infection is clinically known to induce testicular swelling, termed orchitis, and potentially impact male sterility, but the underlying mechanisms remain unclear. Previous reports suggested t...

    Authors: Hsin-Wei Wang, Hsing-Han Li, Shih-Cheng Wu, Cheng-Kang Tang, Hui-Ying Yu, Ya-Chen Chang, Pei-Shan Sung, Wei-Liang Liu, Matthew P. Su, Guann-Yi Yu, Li-Rung Huang, Chun-Hong Chen and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2023 30:12
    Content type: Research Published on:

  30. The association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to investigate M splicing in various human influenza A viruses and characterize...

    Authors: Yi-Ju Han, Kuo-Ming Lee, Guan-Hong Wu, Yu-Nong Gong, Avijit Dutta and Shin-Ru Shih
    Citation: Journal of Biomedical Science 2023 30:10
    Content type: Research Published on:

  31. Pseudomonas aeruginosa intestinal carriage rates are significantly higher in immunosuppressed individuals and hospitalized patients who therefore have increased risk of infections and antibiotic-associated diarrh...

    Authors: Rajendra Prasad Janapatla, Anna Dudek, Chyi-Liang Chen, Chih-Hsien Chuang, Kun-Yi Chien, Ye Feng, Yuan-Ming Yeh, Yi-Hsin Wang, Hsin-Ju Chang, Yuan-Chuan Lee and Cheng-Hsun Chiu
    Citation: Journal of Biomedical Science 2023 30:9
    Content type: Research Published on:

  32. Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which ag...

    Authors: Jiajing Yan, Yibing Chen, Minhua Luo, Xinyu Hu, Hongsheng Li, Quentin Liu and Zhengzhi Zou
    Citation: Journal of Biomedical Science 2023 30:8
    Content type: Review Published on:

  34. This work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated blood glucose as a prerequisite in diabetic cataractogenesis. Novel evidence in our model...

    Authors: Ehsan Ranaei Pirmardan, Yuanlin Zhang, Aliaa Barakat, Marzieh Naseri, Christoph Russmann and Ali Hafezi-Moghadam
    Citation: Journal of Biomedical Science 2023 30:6
    Content type: Research Published on:

  35. Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral functions during a viral invasion. However, co-evolution and co-adaptation between viruses and autophagy have armed vir...

    Authors: Tong Chen, Shaoyu Tu, Ling Ding, Meilin Jin, Huanchun Chen and Hongbo Zhou
    Citation: Journal of Biomedical Science 2023 30:5
    Content type: Review Published on:

  36. The leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are still unsatisfactory. The understanding of potential molecular targets is necessary for clinic...

    Authors: Onsurang Wattanathamsan, Naphat Chantaravisoot, Piriya Wongkongkathep, Sakkarin Kungsukool, Paninee Chetprayoon, Pithi Chanvorachote, Chanida Vinayanuwattikun and Varisa Pongrakhananon
    Citation: Journal of Biomedical Science 2023 30:4
    Content type: Research Published on:

  37. The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal cells. The dynamic cellular composition and functional charac...

    Authors: Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin and Hsing-Chen Tsai
    Citation: Journal of Biomedical Science 2023 30:3
    Content type: Review Published on:

  38. Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well eluci...

    Authors: Seulgi Jeon, Hee Jin, Jin-Mo Kim, Youmin Hur, Eun Joo Song, Yoon-Jin Lee, Younghwa Na, Jaeho Cho and Yun-Sil Lee
    Citation: Journal of Biomedical Science 2023 30:2
    Content type: Research Published on:

  40. Ovarian cancer has the highest mortality among gynecological cancers due to late diagnosis and lack of effective targeted therapy. Although the study of interplay between cancer cells with their microenvironme...

    Authors: Sheng-Chieh Lin, Yi-Chu Liao, Po-Ming Chen, Ya-Yu Yang, Yi-Hsiang Wang, Shiao-Lin Tung, Chi-Mu Chuang, Yu-Wen Sung, Te-Hsuan Jang, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2022 29:109
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2023 30:54

  41. The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics. Therefore, it would be of gr...

    Authors: Shih-Han Ko, Wan-Yu Chen, Shih-Chieh Su, Hsiu-Ting Lin, Feng-Yi Ke, Kang-Hao Liang, Fu-Fei Hsu, Monika Kumari, Chi-Yu Fu and Han-Chung Wu
    Citation: Journal of Biomedical Science 2022 29:108
    Content type: Research Published on:

  42. Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in the ATXN7 protein, a subunit of the transcr...

    Authors: Anna Niewiadomska-Cimicka, Antoine Hache, Stéphanie Le Gras, Céline Keime, Tao Ye, Aurelie Eisenmann, Imen Harichane, Michel J. Roux, Nadia Messaddeq, Emmanuelle Clérin, Thierry Léveillard and Yvon Trottier
    Citation: Journal of Biomedical Science 2022 29:107
    Content type: Research Published on:

  43. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to motor neuron degeneration. It has been proposed that epigenetic modification and transcri...

    Authors: Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Thanh Nguyen, Jiyeon Chu, Sojung Kim, Suhyun Kim, Hannah L. Ryu, Neil W. Kowall, Hoon Ryu and Junghee Lee
    Citation: Journal of Biomedical Science 2022 29:106
    Content type: Research Published on:

  44. In endothelial cells, phospholipase C (PLC) β1-activated Ca2+ is a crucial second messenger for the signaling pathways governing angiogenesis. PLCβ1 is inactivated by complexing with an intracellular protein call...

    Authors: Sheng-Hung Wang, Jing-Yan Cheng, Hsiu-Hui Tsai, Tzu-Chi Lo, Jung-Tung Hung, Chun-Cheng Lin, Chien-Wei Lee, Yi-Hsuan Ho, Huan-Hsien Kuo, Alice L. Yu and John Yu
    Citation: Journal of Biomedical Science 2022 29:105
    Content type: Research Published on:

  45. Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (ln...

    Authors: Che-Yuan Hu, Bing-Hua Su, Ya-Che Lee, Chung-Teng Wang, Mei-Lin Yang, Wan-Ting Shen, Jing-Ting Fu, Shih-Yao Chen, Wei-Yun Huang, Chien-Hui Ou, Yuh-Shyan Tsai, Feng-Chih Kuo, Ai-Li Shiau, Gia-Shing Shieh and Chao-Liang Wu
    Citation: Journal of Biomedical Science 2022 29:104
    Content type: Research Published on:

  46. Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1), an inflammatory cytokine, under serum-depleted conditions which leads to suppression of lung cancer cell metastasis has been report...

    Authors: Shan-Ying Wu, Jia-Wen Chen, Hsi-Yu Liu, Yi-Ching Wang, Yeh-Shiu Chu, Chi-Ying Huang, Kai-Ying Lan, Hsiao-Sheng Liu and Sheng-Hui Lan
    Citation: Journal of Biomedical Science 2022 29:103
    Content type: Research Published on:

  47. yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S. Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonella (NTS) genes to influence bacteria–host interactions...

    Authors: Hung-Hao Fan, Shiuh-Bin Fang, Yu-Chu Chang, Sheng-Tung Huang, Chih-Hung Huang, Pei-Ru Chang, Wei-Chiao Chang, Lauderdale Tsai-Ling Yang, Pei-Chun Lin and Hung-Yen Cheng
    Citation: Journal of Biomedical Science 2022 29:102
    Content type: Research Published on:

  48. Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms remain unclear. Decidualization is critical for the establishment and maintenance of norma...

    Authors: Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang and Meirong Du
    Citation: Journal of Biomedical Science 2022 29:101
    Content type: Research Published on:

  49. Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endo...

    Authors: Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O’Malley and Sang Jun Han
    Citation: Journal of Biomedical Science 2022 29:100
    Content type: Research Published on:

  50. Sorafenib (SOR) is the first line treatment for advanced hepatocellular carcinoma (HCC), but resistance develops frequently. Tumor-associated macrophages (TAMs) have been reported to affect the progression of ...

    Authors: Hao-Chen Wang, Lin-Ya Haung, Chih-Jung Wang, Ying-Jui Chao, Ya-Chin Hou, Chia-Jui Yen and Yan-Shen Shan
    Citation: Journal of Biomedical Science 2022 29:99
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127