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  1. Review

    Cancer immunotherapies targeting the PD-1 signaling pathway

    Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo

    Journal of Biomedical Science 2017 24:26

    Published on: 4 April 2017

  2. Research

    Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

    Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...

    Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou

    Journal of Biomedical Science 2017 24:25

    Published on: 28 March 2017

  3. Research

    Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

    GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin

    Journal of Biomedical Science 2017 24:23

    Published on: 27 March 2017

  4. Review

    Evaluation of the use of therapeutic peptides for cancer treatment

    Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...

    Susan Marqus, Elena Pirogova and Terrence J. Piva

    Journal of Biomedical Science 2017 24:21

    Published on: 21 March 2017

  5. Research

    Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

    The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individ...

    Phan Nguyen Nhi Nguyen, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Kong Bung Choo

    Journal of Biomedical Science 2017 24:20

    Published on: 7 March 2017

  6. Review

    State of the art in anti-cancer mAbs

    Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...

    S. M. Chiavenna, J. P. Jaworski and A. Vendrell

    Journal of Biomedical Science 2017 24:15

    Published on: 20 February 2017

  7. Review

    Neuroblastoma treatment in the post-genomic era

    Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...

    Maria Rosaria Esposito, Sanja Aveic, Anke Seydel and Gian Paolo Tonini

    Journal of Biomedical Science 2017 24:14

    Published on: 8 February 2017

  8. Review

    Macrophage activation and polarization in post-infarction cardiac remodeling

    Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, ev...

    Aleksandra Gombozhapova, Yuliya Rogovskaya, Vladimir Shurupov, Mariya Rebenkova, Julia Kzhyshkowska, Sergey V. Popov, Rostislav S. Karpov and Vyacheslav Ryabov

    Journal of Biomedical Science 2017 24:13

    Published on: 7 February 2017

  9. Research

    Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation

    Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation ...

    Anja Schwarz, Gabriel A. Bonaterra, Hans Schwarzbach and Ralf Kinscherf

    Journal of Biomedical Science 2017 24:12

    Published on: 7 February 2017

  10. Review

    Escape from IFN-γ-dependent immunosurveillance in tumorigenesis

    Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...

    Chiou-Feng Lin, Chih-Ming Lin, Kang-Yun Lee, Szu-Yuan Wu, Po-Hao Feng, Kuan-Yuan Chen, Hsiao-Chi Chuang, Chia-Ling Chen, Yu-Chih Wang, Po-Chun Tseng and Tsung-Ting Tsai

    Journal of Biomedical Science 2017 24:10

    Published on: 1 February 2017

  11. Review

    Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications

    Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Du...

    Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Moonhee Park, Lin-Woo Kang and Sang Hee Lee

    Journal of Biomedical Science 2017 24:9

    Published on: 31 January 2017

  12. Review

    Harnessing the early post-injury inflammatory responses for cardiac regeneration

    Cardiac inflammation is considered by many as the main driving force in prolonging the pathological condition in the heart after myocardial infarction. Immediately after cardiac ischemic injury, neutrophils ar...

    Bill Cheng, H. C. Chen, I. W. Chou, Tony W. H. Tang and Patrick C. H. Hsieh

    Journal of Biomedical Science 2017 24:7

    Published on: 13 January 2017

  13. Research

    Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma

    The DACT (Dishevelled-associated antagonist of β-catenin) family of scaffold proteins may play important roles in tumorigenesis. However, the epigenetic changes of DACT1, 2, 3 and their effect on esophageal squam...

    Yan-li Guo, Bao-En Shan, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Su-Peng Shen, Xin Guo, Jia Liang and Gang Kuang

    Journal of Biomedical Science 2017 24:6

    Published on: 11 January 2017

  14. Review

    PPARs modulate cardiac metabolism and mitochondrial function in diabetes

    Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, wh...

    Ting-Wei Lee, Kuan-Jen Bai, Ting-I Lee, Tze-Fan Chao, Yu-Hsun Kao and Yi-Jen Chen

    Journal of Biomedical Science 2017 24:5

    Published on: 10 January 2017

  15. Research

    Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin

    Lytic reactivation of EBV has been reported to play an important role in human diseases, including NPC carcinogenesis. Inhibition of EBV reactivation is considered to be of great benefit in the treatment of vi...

    Chung-Chun Wu, Chih-Yeu Fang, Yu-Jhen Cheng, Hui-Yu Hsu, Sheng-Ping Chou, Sheng-Yen Huang, Ching-Hwa Tsai and Jen-Yang Chen

    Journal of Biomedical Science 2017 24:2

    Published on: 5 January 2017

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.