Viral and host proteins involved in picornavirus life cycle

Table 2 Cellular proteins involved in picornaviral IRES-mediated translation

Proteins	Binding sites/associated viral proteins	Viruses	Refs
PTB	IRES, 3C	PV, HRV, EMCV, FMDV, TMEV, HAV	[130–136]
nPTB	IRES	PV, TMEV	[135, 143]
PCBP1	Cloverleaf, IRES	PV, HRV	[93, 153]
PCBP2	Cloverleaf, IRES, 2A, 3CD, 3C	PV, HRV, HAV, CVB3	[94, 152–154, 156, 170]
Unr	IRES	PV, HRV	[139, 157]
La	IRES, 3C	PV, HRV, HAV, CVB3, EMCV	[147, 148, 150, 151, 171]
ITAF45	IRES	FMDV	[124]
hnRNP A1	IRES	HRV2, EV71	[158, 159]
Nucleolin/C23	IRES	PV, HRV	[162]
DRBP 76: NF45 heterodimer	IRES	HRV2	[163, 164]
GAPDH	IRES	HAV	[137, 172]
FBP2	IRES	EV71	[168]
PABP	IRES	PV, EMCV	[125, 173]

*PTB, polypyrimidine tract-binding protein; nPTB, neural polypyrimidine tract-binding protein; PCBP, poly(rC) binding protein; Unr, upstream element binding protein; La, Lupus autoantigen; hnRNP, heterogeneous nuclear ribonucleoprotein; DRBP 76: NF45 heterdimer, dsRNA binding protein 76: NF45 heterdimer; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; FBP2, far upstream element binding protein 2; PABP, poly(A)-binding protein.

ISSN: 1423-0127