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Table 2 Cellular proteins involved in picornaviral IRES-mediated translation

From: Viral and host proteins involved in picornavirus life cycle

Proteins Binding sites/associated viral proteins Viruses Refs
PTB IRES, 3C PV, HRV, EMCV, FMDV, TMEV, HAV [130136]
nPTB IRES PV, TMEV [135, 143]
PCBP1 Cloverleaf, IRES PV, HRV [93, 153]
PCBP2 Cloverleaf, IRES, 2A, 3CD, 3C PV, HRV, HAV, CVB3 [94, 152154, 156, 170]
Unr IRES PV, HRV [139, 157]
La IRES, 3C PV, HRV, HAV, CVB3, EMCV [147, 148, 150, 151, 171]
ITAF45 IRES FMDV [124]
hnRNP A1 IRES HRV2, EV71 [158, 159]
Nucleolin/C23 IRES PV, HRV [162]
DRBP 76: NF45 heterodimer IRES HRV2 [163, 164]
GAPDH IRES HAV [137, 172]
FBP2 IRES EV71 [168]
PABP IRES PV, EMCV [125, 173]
  1. *PTB, polypyrimidine tract-binding protein; nPTB, neural polypyrimidine tract-binding protein; PCBP, poly(rC) binding protein; Unr, upstream element binding protein; La, Lupus autoantigen; hnRNP, heterogeneous nuclear ribonucleoprotein; DRBP 76: NF45 heterdimer, dsRNA binding protein 76: NF45 heterdimer; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; FBP2, far upstream element binding protein 2; PABP, poly(A)-binding protein.