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Table 2 Comparison of group-specific motifs identified in this study to the PROSITE motifs.

From: Identification of group specific motifs in Beta-lactamase family of proteins

A)

Group

Pattern

Sensitivity

Specificity

A

S-[DG]-N-x(1,2)-A-[ACGNST]-x(2)-[ILMV]-x(4)-[AGSTV]

70.270

99.048

B

H-x-[DEH]-x-D-H

82.556

100

C

S-x-[AEGQST]-K-x(2,4)-T

80.851

90.297

D

S-T-[FY]-K-[IV]-x(2)-[AST]-[LMV]-[FILM]-[AG]-x-[ADEQS]-x(3)-[ILV]

71.429

97.561

E

D-[IV]-R-x(3)-E

80.435

88.095

F

G-x(2,3)-F-x-[GST]-x-[QST]-D-x(1,2)-E-[IV]-[IL]-[AIL]-x-[GL]-x-[AES]

87.5

100

B)

   

Class

Pattern

Sensitivity

Specificity

A

[FY]-x-[LIVMFY]-{E}-S-[TV]-x-K-x(3)-{T}-[AGLM]-{D}-{KA}-[LC]

42.4

97.5

B

[LI]-x-[STN]-[HN]-x-H-[GSTAD]-D-x(2)-G-[GP]-x(7,8)-[GS]

1.8

100

C

[FY]-E-[LIVM]-G-S-[LIVMG]-[SA]-K

7.5

69

D

[PA]-x-S-[ST]-F-K-[LIV]-[PALV]-x-[STA]-[LI]

41.1

100

E

Information not available

  

E

Information not available

  
  1. A) Group-specific motifs identified in this study. B) Motifs available in PROSITE database for class A, B, C and D lactamases