Sodium current recorded on HEK293T cells transfected with SCN5A WT, or mutant plasmids. (A) Representative current traces. Protocol used was shown in inset. (B) Current-voltage (I-V) relationship of WT, p.I848fs, p.R965C, and p.1876insM SCN5A channels (n = 9, 7, 7 and 11 respectively). GFP was used as a negative control and was also shown (n = 4). (C) Histogram of current density recorded at -20 mV. The current densities between WT and p.R965C or WT and p.1876insM were not statistically significance.