Figure 2From: Distinct functional defect of three novel Brugada syndrome related cardiac sodium channel mutationsSodium current recorded on HEK293T cells transfected with SCN5A WT, or mutant plasmids. (A) Representative current traces. Protocol used was shown in inset. (B) Current-voltage (I-V) relationship of WT, p.I848fs, p.R965C, and p.1876insM SCN5A channels (n = 9, 7, 7 and 11 respectively). GFP was used as a negative control and was also shown (n = 4). (C) Histogram of current density recorded at -20 mV. The current densities between WT and p.R965C or WT and p.1876insM were not statistically significance.Back to article page