Figure 6
From: Distinct functional defect of three novel Brugada syndrome related cardiac sodium channel mutations
Immunocytochemistry staining revealed by confocal image (total cells analyzed were 25, 18, 6, and 9 for WT, p.I848fs, p.R965C, and p.1876insM respectively from 7 independent experiments). The presence of red fluorescence (anti-myc antibody) at cytoplasmic membrane indicated that WT as well as other mutants were all trafficking competent. The red spot at the center of cell might be immature SCN5A protein in ER.