The change in Cα distances between the residues S108 and D287, both of which are postulated to be involved in heme and substrate binding, as a function of time. (A). Change in the CαRMSD plot of the hydrophobic patches with respect to the starting structure for WT and MT during the course of the simulation (B). WT and MT plots are rendered in black and red respectively. The figure was prepared using XMGRACE (38).