Effects of simvastatin on HSA secretion from HepG2 cells. Cells were exposed to various concentrations (0, 0.5, 1, 5, 10 μM) of simvastatin for 24 hours. HSA secretion was measured by ELISA. Data presented are mean ± SD from three independent experiments performed in triplicate. *P < 0.05, **P < 0.01 vs. without simvastatin.