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Table 4 Binding parameters of [3H] QNB against atropine in the corpus striatum of Control, Diabetic and Diabetic+Insulin treated group rats

From: Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats

Experimental Group

Best-fit model

Log (EC50)

Ki

Hill slope

Control

One-site

-7.076

2.10 × 10-8

0.9832

Diabetic

One-site

-6.818

3.80 × 10-8

0.9883

Insulin treated diabetic

One-site

-6.913

3.05 × 10-8

0.9889

  1. Values are mean of 4–6 separate experiments. Each group consist of 6–8 rats