Figure 8

Schematic summary of the apoptotic pathway involved in denbinobin-induced A549 cell apoptosis. Denbinobin caused Akt inactivation, leading to Bad dephosphorylation, mitochondrial dysfunction, and subsequent cell apoptosis. Denbinobin also activated ASK1 through ROS generation to cause JNK/AP-1 activation, which in turn induced Bim expression, ultimately resulting in A549 cell apoptosis.