Figure 4
From: Recent advances in biomedical applications of accelerator mass spectrometry
Proposed mechanism of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG, a well known DNA oxidative damage biomarker) metabolism in MCF-7 human breast cancer cells, where PNP stands for purine nucleoside phosphorylase, HGPRT for hypoxanthine-guanine phosphoribosyltransferase, RNA Pol for RNA polymerase, DNA Pol for DNA polymerase, RR for ribonucleotide reductase, and BER for base excision repair, respectively. MTH1 is a pyrophosphatase capable of cleaving the pyrophosphate either from 8-oxodGTP or 8-oxoGTP, thus preventing the accumulation of a potentially mutagenic species.