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Figure 3 | Journal of Biomedical Science

Figure 3

From: Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening

Figure 3

Cdk5 inhibitors dose-dependently inhibit NMHC-B phosphorylation in Cdk5/p25 transfected HEK293 cells. A. Roscovitine dose-dependently inhibits pSerCdk phosphorylation with IC50 1.18 μM. B. WL compound dose-dependently inhibits pSerCdk phosphorylation with IC502.55 μM. C. AZ compound dose-dependently inhibits pSerCdk phosphorylation with IC50 4.36 μM. A Western blot of pSerCdk substrate in control and in cells treated with different concentrations of inhibitor is shown next to their respective inhibition curves.

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