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Figure 2 | Journal of Biomedical Science

Figure 2

From: Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke

Figure 2

Immunohistochemical evaluation of oil smoke exposure (OSE) on lung tissues. Lung tissues were paraffin-embedded, sectioned, and stained brown with antibodies to VCAM-1 (A-C) or HEL (D-F). All images are × 200. (A) Endothelial cells in the capillaries of control rats (0 min OSE) did not stain for VCAM-1. (B) The endothelial cells of medium-sized vessels stained strongly for VCAM-1 after 120 min OSE. (C) When pretreated with the NK-1 receptor antagonist L733060, the endothelial cells in capillaries and medium- to large-sized vessels stained weakly for VCAM-1 after 120 min OSE. (D) Endothelial cells in the capillaries of control rats (0 min OSE) did not stain for HEL. (E) Endothelial cells in capillaries and lymphatic-like channels are positive for HEL after 120 min OSE. (F) When pretreated with L733060, endothelial cells in capillaries are positive and pneumocytes are negative for HEL after 120 min OSE.

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Journal of Biomedical Science

ISSN: 1423-0127