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Table 1 Amount of substance P and reactive oxygen species (ROS) in plasma following oil smoke exposure (OSE)

From: Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke

 

Control (n = 8)

OSE (n = 8)

L733060+OSE (n = 8)

Lovastatin+OSE (n = 8)

Vitamin E+OSE (n = 8)

Catechins+OSE (n = 8)

P-value^

Substance-P (pg/mL)

   1 h after OSE

1.83 ± 0.44

54.71 ± 9.40a

23.00 ± 4.58b

48.29 ± 9.44a

27.57 ± 4.63

24.71 ± 4.83

< 0.001*

   8 h after OSE

1.82 ± 0.50

72.93 ± 7.31a

38.99 ± 6.21a, b

57.13 ± 7.94a

51.38 ± 6.74a, †

45.50 ± 5.42a, †

< 0.001*

   24 h after OSE

1.96 ± 0.48

61.44 ± 6.69a

35.86 ± 4.61a

58.25 ± 6.20a

52.63 ± 6.82a, †

46.50 ± 5.72a, †

< 0.001*

Plasma ROS (counts/10 s)

   1 h after OSE

103.86 ± 8.08

966.29 ± 107.17a

642.43 ± 96.50a

730.89 ± 115.32a

597.14 ± 77.70a

522.57 ± 87.07

< 0.001*

   8 h after OSE

91.63 ± 6.78

2103.13 ± 204.06a, †

954.75 ± 68.99a, b

1502.25 ± 129.07a, †

1169.38 ± 145.79a, b, †

922.25 ± 112.51a, b, †

< 0.001*

   24 h after OSE

108.43 ± 8.76

1806.16 ± 111.21a, †

1270.14 ± 127.84a, †

1325.29 ± 133.98a, †

1193.43 ± 192.99a, †

1185.71 ± 109.51a, †

< 0.001*

  1. ^ P-values based on ANOVA test. Pair-wise multiple comparisons between groups determined using Scheffe's test.
  2. * Statistical significance, P < 0.05
  3. a Significantly different from control group at the respective time interval
  4. bSignificantly different from OSE group at the respective time interval
  5. †Significantly different from treatment results at 1 h after OSE