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Table 1 Effects of test agents on baseline MSAP, HR and power density of vasomotor components of SAP spectrum

From: Activation of estrogen receptor β-dependent nitric oxide signaling mediates the hypotensive effects of estrogen in the rostral ventrolateral medulla of anesthetized rats

Treatment

Maximal changes in

MSAP (mmHg)

HR (bpm)

Power Density (mmHg2)

aCSF

+3.3 ± 0.4

+4.9 ± 0.6

+0.7 ± 0.5

ICI 182780 (0.25 pmol)

+3.3 ± 0.6

+5.5 ± 0.8

+0.7 ± 0.5

ICI 182780 (0.5 pmol)

+2.5 ± 0.5

+3.5 ± 0.8

+0.6 ± 0.6

R,R-THC (50 pmol)

+6.4 ± 0.6

+6.5 ± 1.0

+0.8 ± 0.4

MPP (1 nmol)

+6.1 ± 0.8

+6.6 ± 0.8

+0.9 ± 0.7

L-NAME (5 nmol)

+3.8 ± 0.6

+5.6 ± 0.6

+0.9 ± 0.6

SMT (25 pmol)

+3.7 ± 0.8

+5.3 ± 0.8

+0.7 ± 0.5

7-NI (0.5 pmol)

-2.7 ± 0.8

-3.3 ± 0.5

-0.6 ± 0.8

L-NIO (2.5 pmol)

-1.9 ± 0.8

-3.6 ± 0.7

-1.0 ± 0.6

  1. Values are mean ± S.E.M., n = 6–7 animals per experimental group. No significant difference was detected among groups in the paired t-test.