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Figure 4 | Journal of Biomedical Science

Figure 4

From: DNA damage induces nuclear translocation of parkin

Figure 4

Nuclear localized parkin promotes DNA excision repair. (A) HCR assays showed Parkin facilitates DNA repair of UV induced DNA lesions in SH-SY5Y cells (pTK-Renilla irradiated by UV-C at 250 J/m2). Values are expressed relative to the transfected undamaged reporter, and represent the mean ± s.d.; n = 3. Asterisks indicate P < 0.05 relative to control by ANOVA with post-hoc Student Neumann-Kiels tests. Western blot analysis showed the expression of wild type parkin and parkin Del3–4 mutant. (B) HCR assays showed the ability of wild type Parkin, Parkin-NLS, and Parkin-NES to regulate DNA repair activities. n = 3. * P < 0.05, ** P > 0.05 relative to control by ANOVA with post-hoc Student Neumann-Kiels tests. Western blot analysis showed the expression of wild type parkin, parkin-NLS, and parkin-NES.

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