Function of marginal islets and diabetic-free frequency of diabetic recipients. (A) Mean blood glucose concentration in mice that received Lt-eGFP- or Lt-TRX-transduced islets. Data are expressed as the mean ± SD from 10 mice in each group. (B) Lt-TRX-transduced islets maintained euglycemia for significantly longer than in the Lt-eGFP-transduced group. Blood glucose concentration was monitored daily after islet implantation. Loss of graft function was defined as a blood glucose concentration > 300 mg/dl on two consecutive days.