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Figure 3 | Journal of Biomedical Science

Figure 3

From: Characterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome

Figure 3

V m -dependent steady-state activation and inactivation of WT and A551T channels A. The normalized peak conductance-Vm relationship. n = 22 for WT and 30 for A551T. B. Vm dependence of steady-state inactivation. Currents were normalized to the maximum current recorded at the test Vm of -20 mV. k = 4.6 ± 0.1 and n = 24 for WT; k = 4.5 ± 0.1 and n = 19 for A551T. C. Vmdependence of steady-state intermediate and fast inactivation. For fast inactivation, k = 8.1 ± 0.2 and n = 9 for WT; k = 7.9 ± 0.2 and n = 8 for A551T. For intermediate inactivation, k = 16.2 ± 1.9 and n = 10 for WT; k = 13.9 ± 2.1 and n = 10 for A551T. Insets: Vm protocols.

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