Figure 5
From: Characterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome
Effects of repeated stimulation on Na+ currents recorded from the wild-type and A551T mutant channels. A. Current traces recorded using the ramp protocol (inset) mimicking the action potential during the 1st, 10th, 50th, and 100th depolarization at the indicated stimulation frequency. B. Normalized peak currents during a train of depolarizing pulses. The currents were normalized to that obtained at the first pulse. n = 11 – 17. **, p < 0.01; ***, p < 0.001.