Figure 6
From: Characterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome
Effects of the A551E and A551V mutations on the steady-state inactivation of Nav1.5 channels. A. Vm dependence of steady-state inactivation. k = 4.5 ± 0.1 and n = 19 for A551T; k = 5.2 ± 0.1 and n = 9 for A551V; k = 5.1 ± 0.1 and n = 8 for A551E. B. Vm dependence of fast inactivation. k = 7.9 ± 0.2 and n = 8 for A551T; k = 8.5 ± 0.3 and n = 9 for A551V; k = 8.9 ± 0.4 and n = 8 for A551E. Insets: Vm protocols (applied at 0.2 Hz).