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Table 1 Laboratory characteristics in age-matched control, diabetic (DM), and insulin-treated diabetic (DMI) rats.

From: Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic Rats

 

Control (n = 21)

DM (n = 36)

DMI (n = 25)

Plasma glucose (mg/dl)

169 ± 4

607 ± 16*(P < 0.001)

397 ± 24†(P < 0.001)

Plasma insulin (μg/L)

2.7 ± 0.22

1.08 ± 0.16*(P < 0.001)

3.29 ± 0.27†(P < 0.001)

Body weight (g)

411 ± 13

235 ± 5*(P < 0.001)

252 ± 5†(P < 0.05)

Heart weight (g)

1.32 ± 0.05

0.89 ± 0.03*(P < 0.001)

0.97 ± 0.03†(P < 0.05)

Ratio heart/body weight (mg/g)

3.51 ± 0.008

3.91 ± 0.012*(P < 0.001)

3.85 ± 0.013

MAP (mmHg)

118 ± 5

94 ± 4*(P < 0.001)

108 ± 5†(P < 0.05)

TPR (mmHg/ml/min)

2.21 ± 0.1

2.42 ± 0.09

2.21 ± 0.1

  1. Data are expressed as means ± SEM (*, vs. control; †, vs. DM). DM, STZ-diabetes; DMI, insulin-treated diabetes; MAP, mean arterial pressure; TPR, total peripheral resistance.