Table 1 General profiles in sham-operated (SO) and bile-duct-ligated (BDL) rats receiving armepavine (Arm), silymarin (sil) or vehicle (0.7% CMC) treatment.

BW (g)

386 ± 22

302 ± 21*

335 ± 17.8*^,#

333 ± 16.1*^,#

345 ± 22.0*^,#

LW (g)

19.5 ± 0.8

29.2 ± 0.4*

27.4 ± 0.1*^,#

27.5 ± 1.1*^,#

26.3 ± 0.3*^,#

ALT (U/L)

76 ± 5.0

756 ± 19*

545 ± 10*^,#

536 ± 4 *^,#

434 ± 11*^,#

AST (U/L)

43 ± 2

168 ± 21*

128 ± 8*^,#

127 ± 10*^,#

73 ± 9*^,##

Collagen

(mg/g liver)

3.42 ± 0.59

6.63 ± 0.31*

5.36 ± 0.12*^,#

6.18 ± 0.16*

4.38 ± 0.33*^,#

α-SMA/α-tubulin ratio (%)

100 ± 1

182 ± 8*

150 ± 3*^,#

173 ± 8*

141 ± 12*^,#

Fibrosis score

0 ± 0

2.42 ± 0.20*

1.42 ± 0.20*^,#

1.85 ± 0.14*^,#

1.28 ± 0.18*^,##

Necrosis score

0 ± 0

1.17 ± 0.31**

0.29 ± 0.18*^,##

0.38 ± 0.18*^,#

0.50 ± 0.22*^,#