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Table 2 Immunostaining expression of cytoplasmic EGFR in normal parenchymal and RCC tissues.

From: Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma

Characteristic

Patients

Cytoplasmic EGFR protein expression

(mean score ± SE)

P value*

No. (%)

Normal renal tubular cells

RCC

 

Total

   

<0.001

Sex

    

   Male

46 (73)

199.1 ± 13.1

106.7 ± 7.8

<0.001

   Female

17 (27)

214.1 ± 18.5

92.9 ± 11.3

<0.001

   P value†

 

0.54

0.345

 

Grade

    

   I

9 (14)

176.7 ± 28.7

112.2 ± 17.9

0.048

   II

29 (46)

209 ± 14.8

97.9 ± 9.9

<0.001

   III

9 (14)

242.2 ± 20.1

122.2 ± 17.1

<0.001

   IV

14 (23)

177.9 ± 28.2

96.4 ± 11.3

0.011

   ND

2 (3)

240 ± 60

95 ± 65

 

   P value‡

 

0.257

0.556

 

Stage

    

   Organ-confined (T1-2N0M0)

41 (65)

190.5 ± 13.4

94.9 ± 7.4

<0.001

   Locally advanced (T3-4N0M0)

15 (24)

242 ± 18.5

120.7 ± 15.5

<0.001

   Metastatic (N1-2 or M1)

7 (11)

194.3 ± 36.7

112.9 ± 18.1

0.099

   P value‡

 

0.129

0.215

 

Histological type

    

   Conventional

54 (86)

209.3 ± 10.8

102.8 ± 7

<0.001

   Non-conventional

9 (14)

166.7 ± 38.2

104.4 ± 16.9

0.15

   P value†

 

0.167

0.929

 
  1. NOTE: Expression of cytoplasmic EGFR protein was examined by immunohistochemistry on a scale from 0 to 300 (percent positive cells × staining intensity). Non-conventional type included papillary, chromophobe, sarcomatoid and collecting duct. Abbreviations: RCC, renal cell carcinoma; SE, standard error; TNM, tumor-node-metastasis; ND, not determined. *: paired sample t test, †: Independent-sample t test for two groups, ‡: One-way ANOVA for three or more groups
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Journal of Biomedical Science

ISSN: 1423-0127