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Figure 2 | Journal of Biomedical Science

Figure 2

From: CHD5 is down-regulated through promoter hypermethylation in gastric cancer

Figure 2

CHD5 promoter is hypermethylated in gastric cancer. A, CHD5 has a typical CpG island (CGI) around its exon 1. CGI was plotted by GeneTool program. The positions of BGS and MSP primers were indicated as arrows. B, The methylation status of CHD5 promoter in gastric cancer cells was determined by methylation specific PCR. M: methylation; U: unmethylation. C, The methylation status of CHD5 promoter in primary gastric cancer tissues was determined by methylation specific PCR as in B. Normal gastric tissues and adjacent non-tumor tissues were used as controls. N1 and N2 are normal gastric tissues. T1 and T2 indicate gastric carcinoma tissues while A1 and A2 represent adjacent non-tumor tissues. Represented results were shown. D, Methylation of CHD5 promoter in gastric cancer cell lines and primary gastric carcinoma tissues was confirmed by BGS. Each circle indicates one CpG site and circles filled in black represent methylated CpG sites. One row of circles represents a single colony.

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