Table 1 Classification of vertebrate MMPs, their substrate and chromosomal location

MMP-1

Collagenase-1

11q22.2-22.3

Collagen II<I<III,VII,VIII,X,XI,Casein, perlecan, entactin, laminin, pro-MMP-1,2,9,serpins

MMP-8

Collagenase-2

11q22.2-22.3

Collagen I>II>III>VII,VII,X,entactin,gelatin

MMP-13

Collagenase-3

11q22.2-22.3

Collagen II>III>I,VII,X,XVIII,gelatin,entactin,tenascin,aggregan

MMP-18

Collagenase-4

Not in humans

Collagen I,II,III,gelatin

MMP-2

Gelatinase-A

16q13

Gelatin, fibronectin, elastin, laminin, collagen I,III,IV,V,VII,X,XI

MMP-9

Gelatinase-B

20q11.2-q13.1

vitronectin,decorin,plasminogen Gelatin,CollagenI,IV,V,VII,X,XI,XVIII,vitronectin,Elastin,laminin,fibronectin, ProMMP-9 proMMP-2

MMP-3

Stromelysins-1

11q22.2-22.3

Laminin, aggregan gelatin, fibronectin

MMP-10

Stromelysins-2

11q22.2-22.3

CollagenI,III,IV,gelatin,elastin,proMMP-1,8,10

MMP-11

Stromelysins-3

22q11.2

Fibronectin,laminin,aggregan,gelatin

MMP-12

Metalloelastase

11q22.2-22.3

Elastin, gelatin, collagen I,IV, fibronectin, laminin, vitronectin, proteoglycan

MMP-7

Matrilysin-1

11q22.2-22.3

Collagen I,IV,V,IX,X,XI,XVIII, Fibronectin,laminin,gelatin,aggregan,,gelatin,proMMP-9

MMP-26

Matrilysin-2

11q22.2

Gelatin, Collagen IV,proMMP-9

MMP-20

Enamelysin

11q22

Laminin,amelogenin,aggregan

MMP-14

MT1-MMP

14q12.2

Collagen I,II,III,aggregan,laminin,gelatin,proMMP-2,13

MMP-15

MT2-MMP

16q12.2

Proteoglycans,proMMP-2

MMP-16

MT3-MMP

8q21

CoolagenIII,fironectin,proMMP-2

MMP-17

MT4-MMP

12q24

Gelatin,fibrinogen,proMMP-2

MMP-24

MT5-MMP

20q11.2

fibrinogen, Gelatin,proMMP-2

MMP-25

MT6-MMP

16q13.3

Collagen IV,gelatin,proMMP-2,9

MMP-19

Stromelysin-4

12q14

Collagen I,IV,Tenascin,Gelatin,Laminin

MMP-21

XMMP (Xenopus)

-

Gelatin

MMP-22

CMMP (Chicken)

-

-

MMP23

Cysteine array

1p36.3

Gelatin

MMP-27

(CA)

11q24

-

MMP28

CA-MMP Epilysin

17q11.2

Casein