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Table 2 Functional Polymorphism of MMP-1(-16071G/2G), MMP-2 (-1306 C>T), MMP-3 (-1171 5A/6A) MMP-9 (P574R C>G;-1562 C>T) and TIMP-2 (-418 GC or CC) in potentially malignant and malignant head- and neck malignancies

From: Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck

Study Country Year MMPs type Mode of detection Polymorphism Case/Control group OR 95%CI p-value Tumour
Chaudhary et al[57] India 2010 MMP-3 PCR-RFLP -1171 5A/6A 101/126
135/126
2.26
1.94
1.22-4.20
1.06-3.51
0.01
0.03
HNSCC
OSMF
Shimizu et al[36] Japan 2008 MMP-1 IL-8 PCR-RFLP, IHC -1607 1G/2G
IL-8-251 A/A
- -
-
-
-
0.001
0.003
TSCC
Wu et al[61] China 2008 MMP-9 PCR-RFLP P574R C>G - 4.1 1.58-10.52 0.00 ESCC
Tu et al[62] Taiwan 2007 MMP-9 PCR-RFLP -1562 C>T 192/191
73/191
- - 0.029 OSCC
OSMF
Nasr et al[38] North Africa 2007 MMP-9
MMP-1
PCR-RFLP -1562 C/T
-1607 1G/2G
174/171 -
2.9
- -
0.02
-
NPC
Vairaktaris et al[63] Greece 2008 MMP-9 PCR-RFLP -1562 C/T 152/162 1.9 1.21-3.06 0.05 OSCC
Vairaktaris et al[55] Greece 2007 MMP-3
MMP-1
PCR-RFLP -1171 5A/6A
-1607 1G/2G
160/156
141/156
2.2
-
1.0-4.5
-
< 0.05
< 0.05
OSCC
Nishizawa et al[37] Japan 2007 MMP-1
MMP-3
PCR-RFLP -1607 1G/2G
-1171 5A/6A
170/164 2.4
-
1.5-4.6
-
0.000
-
OSCC
O-Charoenrat and Khantapura[51] Thailand 2006 TIMP-2
MMP-2
PCR-RFLP -418GC or CC
-1306C-->T
239/250
239/250
1.43
1.97
0.98-2.08
1.23-3.15
-
-
HNSCC
Tu et al[56] Taiwan 2006 MMP-3 PCR-RFLP -1171 5A/6A 150/98
71/98
1.7
2.62
0.84-3.445
1.20-5.71
0.18
0.01
OSCC
OSF
Cao and Li[41] China 2006 MMP-1 PCR-RFLP -1607 1G/2G 96/120 2.2 1.5-3.4 0.000 OSCC
Zinzindohoue et al[42] France 2004 MMP-1
MMP-3
PCR-RFLP -1607 1G/2G
-1171 5A/6A
126/249 0.37
-
0.2-0.7
-
0.003
-
HNSCC
Lin et al[52] Taiwan 2004 MMP-2 PCR & dHPLC -1306 C>T 121/147
58/147
2.0 - - OSCC
OSF
Hashimoto et al[44] Japan 2004 MMP-1
MMP-3
PCR-RFLP -1607 1G/2G
-1171 5A/6A
140/223 1.6
NS
-
-
0.04
NS
HNSCC
  1. [PCR-RFLP = Polymerase chain reaction-fragment length polymorphism, dHPLC = Denaturing high-performance liquid chromatography, ESCC = Esophageal squamous cell carcinoma, BSCC = Buccal squamous cell carcinoma, OSCC = Oral squamous cell carcinoma, OSMF = Oral sub-mucous fibrosis, NPC = Nasopharyngeal carcinoma, HNSCC = Head and neck squamous cell carcinoma, TC = Tongue squamous cell Carcinoma, NS = Not significant]