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Table 2 Functional Polymorphism of MMP-1(-16071G/2G), MMP-2 (-1306 C>T), MMP-3 (-1171 5A/6A) MMP-9 (P574R C>G;-1562 C>T) and TIMP-2 (-418 GC or CC) in potentially malignant and malignant head- and neck malignancies

From: Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck

Study

Country

Year

MMPs type

Mode of detection

Polymorphism

Case/Control group

OR

95%CI

p-value

Tumour

Chaudhary et al[57]

India

2010

MMP-3

PCR-RFLP

-1171 5A/6A

101/126

135/126

2.26

1.94

1.22-4.20

1.06-3.51

0.01

0.03

HNSCC

OSMF

Shimizu et al[36]

Japan

2008

MMP-1 IL-8

PCR-RFLP, IHC

-1607 1G/2G

IL-8-251 A/A

-

-

-

-

-

0.001

0.003

TSCC

Wu et al[61]

China

2008

MMP-9

PCR-RFLP

P574R C>G

-

4.1

1.58-10.52

0.00

ESCC

Tu et al[62]

Taiwan

2007

MMP-9

PCR-RFLP

-1562 C>T

192/191

73/191

-

-

0.029

OSCC

OSMF

Nasr et al[38]

North Africa

2007

MMP-9

MMP-1

PCR-RFLP

-1562 C/T

-1607 1G/2G

174/171

-

2.9

-

-

0.02

-

NPC

Vairaktaris et al[63]

Greece

2008

MMP-9

PCR-RFLP

-1562 C/T

152/162

1.9

1.21-3.06

0.05

OSCC

Vairaktaris et al[55]

Greece

2007

MMP-3

MMP-1

PCR-RFLP

-1171 5A/6A

-1607 1G/2G

160/156

141/156

2.2

-

1.0-4.5

-

< 0.05

< 0.05

OSCC

Nishizawa et al[37]

Japan

2007

MMP-1

MMP-3

PCR-RFLP

-1607 1G/2G

-1171 5A/6A

170/164

2.4

-

1.5-4.6

-

0.000

-

OSCC

O-Charoenrat and Khantapura[51]

Thailand

2006

TIMP-2

MMP-2

PCR-RFLP

-418GC or CC

-1306C-->T

239/250

239/250

1.43

1.97

0.98-2.08

1.23-3.15

-

-

HNSCC

Tu et al[56]

Taiwan

2006

MMP-3

PCR-RFLP

-1171 5A/6A

150/98

71/98

1.7

2.62

0.84-3.445

1.20-5.71

0.18

0.01

OSCC

OSF

Cao and Li[41]

China

2006

MMP-1

PCR-RFLP

-1607 1G/2G

96/120

2.2

1.5-3.4

0.000

OSCC

Zinzindohoue et al[42]

France

2004

MMP-1

MMP-3

PCR-RFLP

-1607 1G/2G

-1171 5A/6A

126/249

0.37

-

0.2-0.7

-

0.003

-

HNSCC

Lin et al[52]

Taiwan

2004

MMP-2

PCR & dHPLC

-1306 C>T

121/147

58/147

2.0

-

-

OSCC

OSF

Hashimoto et al[44]

Japan

2004

MMP-1

MMP-3

PCR-RFLP

-1607 1G/2G

-1171 5A/6A

140/223

1.6

NS

-

-

0.04

NS

HNSCC

  1. [PCR-RFLP = Polymerase chain reaction-fragment length polymorphism, dHPLC = Denaturing high-performance liquid chromatography, ESCC = Esophageal squamous cell carcinoma, BSCC = Buccal squamous cell carcinoma, OSCC = Oral squamous cell carcinoma, OSMF = Oral sub-mucous fibrosis, NPC = Nasopharyngeal carcinoma, HNSCC = Head and neck squamous cell carcinoma, TC = Tongue squamous cell Carcinoma, NS = Not significant]