Table 1 Antiviral activity of BPR1P0034.
From: Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity
|  | Concentration (μM) | |||
|---|---|---|---|---|
BPR1P0034 | Amantadine | Zanamivir | ||
IC50 | CC50c | IC50 | IC50 | |
Cytotoxic effect | Â | Â | Â | Â |
   MDCK |  | 6.75 ± 0.08 |  |  |
Influenza virus | Â | Â | Â | Â |
   A/WSN/33 (H1N1)b | 0.21 ± 0.07 |  | > 25 | 0.06 ± 0.02 |
   A/Udorn/72 (H3N2)a | 2.11 ± 0.41 |  | 0.98 ± 0.15 | 0.67 ± 0.23 |
   A/TW/83/05 (H3N2)a | 1.38 ± 0.08 |  | > 25 | 0.92 ± 0.03 |
   A/TW/785/05 (H1N1)a | 0.92 ± 0.11 |  | 0.38 ± 0.24 | 1.06 ± 0.98 |
   B/TW/710/05b | 8.11 ± 3.98 |  | > 25 | 0.03 ± 0.02 |
   B/TW/70325/05b | 1.94 ± 0.72 |  | > 25 | 0.02 ± 0.01 |
   B/TW/99/07b | 8.90 ± 4.16 |  | > 25 | 0.10 ± 0.01 |
Enterovirus 71b | Â | Â | Â | Â |
   TW/1743/98 | > 40 | > 20 | -- | -- |
   TW/4643/98 | > 20 | > 20 | -- | -- |
Echovirus 9b | > 20 | > 20 | -- | -- |