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Table 1 Antiviral activity of BPR1P0034.

From: Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity

  Concentration (μM)
BPR1P0034 Amantadine Zanamivir
IC50 CC50c IC50 IC50
Cytotoxic effect     
   MDCK   6.75 ± 0.08   
Influenza virus     
   A/WSN/33 (H1N1)b 0.21 ± 0.07   > 25 0.06 ± 0.02
   A/Udorn/72 (H3N2)a 2.11 ± 0.41   0.98 ± 0.15 0.67 ± 0.23
   A/TW/83/05 (H3N2)a 1.38 ± 0.08   > 25 0.92 ± 0.03
   A/TW/785/05 (H1N1)a 0.92 ± 0.11   0.38 ± 0.24 1.06 ± 0.98
   B/TW/710/05b 8.11 ± 3.98   > 25 0.03 ± 0.02
   B/TW/70325/05b 1.94 ± 0.72   > 25 0.02 ± 0.01
   B/TW/99/07b 8.90 ± 4.16   > 25 0.10 ± 0.01
Enterovirus 71b     
   TW/1743/98 > 40 > 20 -- --
   TW/4643/98 > 20 > 20 -- --
Echovirus 9b > 20 > 20 -- --
  1. MDCK cells or Vero cells were infected with influenza virus and EV71, respectively, and incubated with different concentrations of BPR1P0034.
  2. IC50was determined with a plaque reduction assaya or a neutralization assayb
  3. cCC50 was determined with an MTT assay
  4. --, not determined
  5. The values are means ± SD of 2--3 independent experiments.