|
Metabolite
|
Control
|
Ischemia-hypoxia
|
Ischemia-hyperoxia
|
|---|
|
Right
|
Left
|
Right
|
Left
|
|---|
|
Alanine
|
0.66 ± 0.05
|
0.60 ± 0.03
|
0.66 ± 0.09
|
0.39 ± 0.07*
|
0.60 ± 0.08
|
|
Choline
|
3.74 ± 0.22
|
3.47 ± 0.13
|
3.88 ± 0.15
|
3.73 ± 0.26
|
3.58 ± 0.16
|
|
Creatine
|
10.99 ± 0.50
|
11.90 ± 0.10
|
12.78 ± 0.75
|
11.44 ± 0.65
|
11.43 ± 0.44
|
|
GABA
|
2.16 ± 0.11
|
1.40 ± 0.08**
|
1.67 ± 0.34
|
1.53 ± 0.28*
|
1.88 ± 0.28
|
|
Glutamate
|
14.44 ± 0.45
|
13.88 ± 0.45*
|
15.96 ± 0.93
|
13.78 ± 0.80
|
13.98 ± 0.70
|
|
Lactate
|
11.88 ± 0.28
|
15.18 ± 0.29**
|
17.01 ± 1.00**
|
13.55 ± 1.10*
|
13.93 ± 0.23**
|
|
Myo-inositol
|
4.98 ± 0.62
|
6.47 ± 0.80
|
7.36 ± 0.40*
|
6.74 ± 0.26*
|
5.63 ± 0.24
|
|
N-acetylaspartate
|
10.29 ± 0.16
|
10.33 ± 0.40
|
12.08 ± 0.50**
|
10.41 ± 0.65
|
10.64 ± 0.60
|
- Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05 and **P < 0.01 compared with controls.
