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Table 1 Effects of ischemia-hypoxia and ischemia-hyperoxia in the fronto-parietal cortex of young rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite Control Ischemia-hypoxia Ischemia-hyperoxia
Right Left Right Left
Alanine 0.66 ± 0.05 0.60 ± 0.03 0.66 ± 0.09 0.39 ± 0.07* 0.60 ± 0.08
Choline 3.74 ± 0.22 3.47 ± 0.13 3.88 ± 0.15 3.73 ± 0.26 3.58 ± 0.16
Creatine 10.99 ± 0.50 11.90 ± 0.10 12.78 ± 0.75 11.44 ± 0.65 11.43 ± 0.44
GABA 2.16 ± 0.11 1.40 ± 0.08** 1.67 ± 0.34 1.53 ± 0.28* 1.88 ± 0.28
Glutamate 14.44 ± 0.45 13.88 ± 0.45* 15.96 ± 0.93 13.78 ± 0.80 13.98 ± 0.70
Lactate 11.88 ± 0.28 15.18 ± 0.29** 17.01 ± 1.00** 13.55 ± 1.10* 13.93 ± 0.23**
Myo-inositol 4.98 ± 0.62 6.47 ± 0.80 7.36 ± 0.40* 6.74 ± 0.26* 5.63 ± 0.24
N-acetylaspartate 10.29 ± 0.16 10.33 ± 0.40 12.08 ± 0.50** 10.41 ± 0.65 10.64 ± 0.60
  1. Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05 and **P < 0.01 compared with controls.