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Table 2 Effects of ischemia-hypoxia and ischemia-hyperoxia in the fronto-parietal cortex of aged rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite Control Ischemia-hypoxia Ischemia-hyperoxia
Right Left Right Left
Alanine 0.63 ± 0.07 0.59 ± 0.04 0.58 ± 0.06 0.93 ± 0.34 0.66 ± 0.03
Choline 3.43 ± 0.09 3.74 ± 0.08 3.87 ± 0.23 3.58 ± 0.15 4.01 ± 0.09
Creatine 11.63 ± 0.24 11.67 ± 0.35 12.49 ± 0.39 10.80 ± 0.35 11.88 ± 0.21
GABA 1.79 ± 0.18 1.28 ± 0.08* 1.54 ± 0.31 1.13 ± 0.35* 2.18 ± 0.25
Glutamate 15.03 ± 0.26 15.09 ± 0.45 15.92 ± 0.80 12.52 ± 0.80** 15.28 ± 0.90
Lactate 12.59 ± 0.30 16.43 ± 0.40*** 16.45 ± 0.83*** 15.91 ± 1.00** 15.66 ± 0.76**
Myo-inositol 5.63 ± 0.46 6.64 ± 0.25 7.02 ± 0.50* 6.11 ± 0.50 6.67 ± 0.33*
N-acetylaspartate 10.69 ± 0.21 11.53 ± 0.37 11.66 ± 0.37 9.65 ± 0.32 11.09 ± 0.36
  1. Concentrations of metabolites (mmol/kg w/w) in aged rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.