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Table 3 Effects of ischemia-hypoxia and ischemia-hyperoxia in the occipital cortex of young rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite

Control

Ischemia-hypoxia

Ischemia-hyperoxia

Right

Left

Right

Left

Alanine

0.64 ± 0.04

0.76 ± 0.08

0.73 ± 0.19

0.73 ± 0.02

0.50 ± 0.04

Choline

3.75 ± 0.05

3.59 ± 0.06

3.88 ± 0.23

4.34 ± 0.25

4.32 ± 0.29

Creatine

10.64 ± 0.10

11.81 ± 0.25**

12.08 ± 0.61

12.97 ± 0.60*

13.21 ± 1.00*

GABA

1.72 ± 0.21

1.76 ± 0.20

2.06 ± 0.54

2.52 ± 0.50*

2.02 ± 0.28

Glutamate

14.55 ± 0.18

14.91 ± 0.29

15.58 ± 1.50

16.17 ± 0.80*

16.02 ± 0.60*

Lactate

12.10 ± 0.51

16.56 ± 0.49***

17.87 ± 0.33***

16.03 ± 1.20**

15.73 ± 0.85**

Myo-inositol

5.67 ± 0.08

8.56 ± 0.40*

8.18 ± 1.14*

8.42 ± 0.90**

8.22 ± 0.80**

N-acetylaspartate

10.15 ± 0.21

11.01 ± 0.62

11.47 ± 0.85

11.85 ± 0.41

11.53 ± 0.44

  1. Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.