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Table 3 Effects of ischemia-hypoxia and ischemia-hyperoxia in the occipital cortex of young rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite Control Ischemia-hypoxia Ischemia-hyperoxia
Right Left Right Left
Alanine 0.64 ± 0.04 0.76 ± 0.08 0.73 ± 0.19 0.73 ± 0.02 0.50 ± 0.04
Choline 3.75 ± 0.05 3.59 ± 0.06 3.88 ± 0.23 4.34 ± 0.25 4.32 ± 0.29
Creatine 10.64 ± 0.10 11.81 ± 0.25** 12.08 ± 0.61 12.97 ± 0.60* 13.21 ± 1.00*
GABA 1.72 ± 0.21 1.76 ± 0.20 2.06 ± 0.54 2.52 ± 0.50* 2.02 ± 0.28
Glutamate 14.55 ± 0.18 14.91 ± 0.29 15.58 ± 1.50 16.17 ± 0.80* 16.02 ± 0.60*
Lactate 12.10 ± 0.51 16.56 ± 0.49*** 17.87 ± 0.33*** 16.03 ± 1.20** 15.73 ± 0.85**
Myo-inositol 5.67 ± 0.08 8.56 ± 0.40* 8.18 ± 1.14* 8.42 ± 0.90** 8.22 ± 0.80**
N-acetylaspartate 10.15 ± 0.21 11.01 ± 0.62 11.47 ± 0.85 11.85 ± 0.41 11.53 ± 0.44
  1. Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.