|
Metabolite
|
Control
|
Ischemia-hypoxia
|
Ischemia-hyperoxia
|
|---|
|
Right
|
Left
|
Right
|
Left
|
|---|
|
Alanine
|
0.61 ± 0.06
|
0.72 ± 0.03
|
0.85 ± 0.21
|
0.88 ± 0.07*
|
0.57 ± 0.12
|
|
Choline
|
3.50 ± 0.14
|
3.61 ± 0.07
|
3.74 ± 0.23
|
3.94 ± 0.36
|
3.72 ± 0.07
|
|
Creatine
|
10.53 ± 0.37
|
10.86 ± 0.24
|
10.76 ± 0.31
|
11.31 ± 0.90
|
11.32 ± 0.46
|
|
GABA
|
1.86 ± 0.24
|
2.02 ± 0.13
|
2.11 ± 0.59
|
3.16 ± 0.60*
|
2.25 ± 0.33
|
|
Glutamate
|
13.89 ± 0.51
|
13.73 ± 0.21
|
13.93 ± 0.46
|
13.71 ± 1.30
|
14.06 ± 0.26
|
|
Lactate
|
12.82 ± 0.49
|
16.12 ± 0.44***
|
16.37 ± 0.53***
|
15.53 ± 0.48**
|
15.69 ± 0.60**
|
|
Myo-inositol
|
6.55 ± 0.18
|
7.06 ± 0.35
|
7.76 ± 0.85*
|
7.63 ± 0.75
|
7.12 ± 0.33
|
|
N-acetylaspartate
|
9.98 ± 0.36
|
10.48 ± 0.30
|
10.87 ± 0.34
|
10.36 ± 0.60
|
10.14 ± 0.38
|
- Concentrations of metabolites (mmol/kg w/w) in aged rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.
