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Table 4 Effects of ischemia-hypoxia and ischemia-hyperoxia in the occipital cortex of aged rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite Control Ischemia-hypoxia Ischemia-hyperoxia
Right Left Right Left
Alanine 0.61 ± 0.06 0.72 ± 0.03 0.85 ± 0.21 0.88 ± 0.07* 0.57 ± 0.12
Choline 3.50 ± 0.14 3.61 ± 0.07 3.74 ± 0.23 3.94 ± 0.36 3.72 ± 0.07
Creatine 10.53 ± 0.37 10.86 ± 0.24 10.76 ± 0.31 11.31 ± 0.90 11.32 ± 0.46
GABA 1.86 ± 0.24 2.02 ± 0.13 2.11 ± 0.59 3.16 ± 0.60* 2.25 ± 0.33
Glutamate 13.89 ± 0.51 13.73 ± 0.21 13.93 ± 0.46 13.71 ± 1.30 14.06 ± 0.26
Lactate 12.82 ± 0.49 16.12 ± 0.44*** 16.37 ± 0.53*** 15.53 ± 0.48** 15.69 ± 0.60**
Myo-inositol 6.55 ± 0.18 7.06 ± 0.35 7.76 ± 0.85* 7.63 ± 0.75 7.12 ± 0.33
N-acetylaspartate 9.98 ± 0.36 10.48 ± 0.30 10.87 ± 0.34 10.36 ± 0.60 10.14 ± 0.38
  1. Concentrations of metabolites (mmol/kg w/w) in aged rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.