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Figure 6 | Journal of Biomedical Science

Figure 6

From: DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and α2-adrenergic receptors

Figure 6

Contribution of the α2-adrenergic pathway to DNIC. The α2-adrenergic receptor was antagonized by an intrathecal yohimbine injection of 30 μg in 20 μl of saline, 15 min before the conditioning stimulus. Yohimbine did not alter the tail-flick latency in the control group (A, C+Yoh line). Unlike naloxone, yohimbine had the ability to reverse the DNIC effect produced by both E50 (A, B) and Fm20 (C, D). Veh, saline; Yoh, yohimbine. Rat numbers: E50+Veh = 9, E50+Yoh = 10, C+Yoh = 10, Fm20+Veh = 9, Fm20+Yoh = 9. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. C+Yoh; # p < 0.05, ## p < 0.01 vs. E50+Yoh (A, B) or vs. Fm20+Veh (C, D), respectively; one-way ANOVA with Bonferroni's post hoc test.

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