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Table 1 Important clinical trials involving bacterial intervention in cancer

From: Bacteria in cancer therapy: a novel experimental strategy

Intervention
(Number
compound)
Clinical
trial
phase
Present status Disease conditions
VNP20009 Phase I Completed Advanced or metastatic solid tumors [64]
TAPET-CD Phase I Completed Head, neck and esophagus cancer [64]
Tf-CRM 107 Phase I Ongoing Brain entral nervous system tumors [48]
IL4-PE Phase I Ongoing Brain entral nervous system tumors [51]
IL13-PE Phase I Ongoing Malignant Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma and Mixed Oligoastrocytoma [49]
  1. VNP20009- A genetically modified strain of S. typhimurium, TAPET-CD- Tumour amplified protein expression therapy using VNP20009 which expresses an E. coli Cytosine deaminase, Tf-CRM 107- Transferrin-Diptheria toxin conjugate, IL4-PE- Interleukin-4-Pseudomonas exotoxin, IL13-PE- Interleukin-13-Pseudomonas exotoxin.