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Table 1 Important clinical trials involving bacterial intervention in cancer

From: Bacteria in cancer therapy: a novel experimental strategy

Intervention

(Number

compound)

Clinical

trial

phase

Present status

Disease conditions

VNP20009

Phase I

Completed

Advanced or metastatic solid tumors [64]

TAPET-CD

Phase I

Completed

Head, neck and esophagus cancer [64]

Tf-CRM 107

Phase I

Ongoing

Brain entral nervous system tumors [48]

IL4-PE

Phase I

Ongoing

Brain entral nervous system tumors [51]

IL13-PE

Phase I

Ongoing

Malignant Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma and Mixed Oligoastrocytoma [49]

  1. VNP20009- A genetically modified strain of S. typhimurium, TAPET-CD- Tumour amplified protein expression therapy using VNP20009 which expresses an E. coli Cytosine deaminase, Tf-CRM 107- Transferrin-Diptheria toxin conjugate, IL4-PE- Interleukin-4-Pseudomonas exotoxin, IL13-PE- Interleukin-13-Pseudomonas exotoxin.
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Journal of Biomedical Science

ISSN: 1423-0127