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Table 1 A comparison between certain biological properties of TXA2 and 8-iso-PGF

From: Platelet function and Isoprostane biology. Should Isoprostanes be the newest member of the Orphan-ligand family?

Lipid Half life
(T1/2)
Plasma Concentration
(endogenous)
Method of synthesis Receptors
TXA 2 20-30
seconds111
TXB2 (1-66 pg/ml)113 Enzymatic26 TPRα & TPRβ31
8-iso-PGF 1-10
minutes112
351-1831 pg/ml (dinordihydro metabolite)114 Non-emzymatic & enzymatic73,115 TPRα80 & TPRβ74,91 and ISR70,74,97