Figure 6
Ultrastructure of podocytes in the kidney of Fabry mouse. Compared with wild-type mice (A, × 15000), foot process effacement and thickening of the basement membrane were noted in Fabry mice kidneys (B, × 12000). After 6 weeks ERT (C, × 12000), foot process fusion appeared in a few glomerular podocytes. The glomerular podocytes of kidneys from mice with gene therapy (2 × 1012 particles of rAAV2/8-hAGA) appeared normal (D, ×12000).