Characterization of the therapeutic antitumor effects generated by treatment with E7-CRT in combination with imiquimod in tumor-bearing mice. C57BL/6 mice (5/group: untreated, imiquimod alone, CRT/E7 alone, and combined group) were implanted with TC-1 (5 × 104/mouse) at d0. Treatment schedules were the same as described in Figure 1. Tumor growth was monitored over time. A) Line graph depicting the tumor sizes in tumor-bearing mice treated with the different regimens. (*, p < .05) B) Kaplan-Meier survival curve of the mice treated with the various regimens (*, p < 0.05, compared between CRT/E7 alone and the combined group). Representative data from one of three independent experiments are shown.