Figure 4
From: Combinatorial gene therapy renders increased survival in cirrhotic rats
Human transgenes detection and fibrinolytic activities. Panels A and B show uPA and MMP-8 proteins in cirrhotic animals, both control and experimental (2nd through 10th days) detected by immunohistochemistry, indicating percentage of positive cells. C, transgenes activity, shows major activity of both trangenes (uPA and MMP-8) at 4 days after treatment. D, both enzymes (MM-2 and MM-9) increment their functional activities only in the cirrhotic animals treated with Ad-uPA plus Ad-MMP-8 and the maximum activity was at 4 days post-treatment.