Figure 5
From: Combinatorial gene therapy renders increased survival in cirrhotic rats
Cellular proliferation and survival. A, PCNA protein (regeneration index) shows increment only with the treatment of combinatorial gene therapy at 2-4 days post treatment. B, gene expression of HGF and c-met determined by semiquantitative RT-PCR that indicate a light increment of both genes on the animals treated with Ad-uPA plus Ad-MMP-8 to respect Ad-β-Gal. C, activated HSC (α-SMA+) show significant decrement after 2 days of treatment with therapeutically gene therapy. D, Survival analysis (Kaplan Meier) of cirrhotic animals in each experimental group. Increment of survival (60 days) in the animals receiving the combined gene therapy is noticeable.