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Table 2 Scatchard analysis of [3H] dopamine binding against dopamine in the cerebral cortex of control, and experimental rats

From: Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Animal status Bmax (fmoles/mg protein) Kd (nM)
Control 23 ± 3.7 2.01 ± 0.05
Diabetic 67 ± 5.7*** 6.17 ± 0.06**
D + I 19.8 ± 4.1ψψψ 2.4 ± 0.05ψψ
D + C 21.7 ± 6.6ψψψ 1.96 ± 0.06ψψ
  1. Values are mean ± S.E.M of 4-6 separate experiments. Each group consist of 6-8 rats *** P < 0.001 when compared to control, ψψψP < 0.001 when compared to diabetic group **P < 0.01 when compared to control group ψψ P < 0.01 when compared to diabetic group.
  2. D + I- Insulin treated diabetic rats
  3. D+C- Curcumin treated diabetic rats