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Table 2 Scatchard analysis of [3H] dopamine binding against dopamine in the cerebral cortex of control, and experimental rats

From: Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Animal status

Bmax (fmoles/mg protein)

Kd (nM)

Control

23 ± 3.7

2.01 ± 0.05

Diabetic

67 ± 5.7***

6.17 ± 0.06**

D + I

19.8 ± 4.1ψψψ

2.4 ± 0.05ψψ

D + C

21.7 ± 6.6ψψψ

1.96 ± 0.06ψψ

  1. Values are mean ± S.E.M of 4-6 separate experiments. Each group consist of 6-8 rats *** P < 0.001 when compared to control, ψψψP < 0.001 when compared to diabetic group **P < 0.01 when compared to control group ψψ P < 0.01 when compared to diabetic group.
  2. D + I- Insulin treated diabetic rats
  3. D+C- Curcumin treated diabetic rats