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Table 3 Scatchard analysis of [3H] dopamine binding against dopamine in the cerebellum of control, and experimental rats

From: Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Animal status

Bmax (fmoles/mg protein)

Kd (nM)

Control

112 ± 5.4

3.8 ± 0.14

Diabetic

22 ± 3.6***

2.3 ± 0.05**

D + I

116 ± 4.3ψψψ

3.2 ± 0.13@@

D + C

91.1 ± 3.87ψψψ

4.0 ± 0.03@@

  1. Values are mean ± S.E.M of 4-6 separate experiments. Each group consist of 6-8 rats ***P < 0.001 when compared to control, ψψψP < 0.001 when compared to diabetic group **P < 0.01 when compared to control group @@P < 0.01 when compared to diabetic group.
  2. D + I- Insulin treated diabetic rats
  3. D+C- Curcumin treated diabetic rats
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Journal of Biomedical Science

ISSN: 1423-0127