Figure 2
From: Regulation of cytokines by small RNAs during skin inflammation
Overview of pentameric ARE motifs and potential miRNA target sequences in psoriasis-relevant cytokines. The pentameric sequence motif, AUUUA, has been shown to be a discriminating motif for AREs which generally consist of clustered and/or overlapping pentamer repeats. miR-16 and miR-369-3p target sequence motifs in the ARE of TNFα, which are also present in multiple psoriasis-relevant cytokines as indicated by green and red bars, respectively. Target sites are shown by blue and purple bars, respectively, for miRNAs that are predicted by the PicTar (pictar.mdc-berlin.de) and TargetScan (targetscan.org) algorithms to target psoriasis-relevant cytokines.