Figure 3
From: Regulation of cytokines by small RNAs during skin inflammation
Overview of the p38-MK2-TTP pathway. Upon normal cellular conditions the p38 MAPK pathway is not activated, which leaves TTP able to bind the ARE in the 3'UTR of ARE-containing mRNAs and recruit mRNA decay enzymes. Upon a stress stimulus, the p38 MAPK pathway is activated, initiating a phosphorylation cascade which result in the phosphorylation of TTP and a consequent 14-3-3-mediated sequestration of TTP from the ARE.