Novel biomarkers predict liver fibrosis in hepatitis C patients: alpha 2 macroglobulin, vitamin D binding protein and apolipoprotein AI

Table 2 Protein spots identified by MALDI/TOF-TOF-MS

Protein^§	GenBank	coverage ratio	regulation	p value^¶
A2M	gi:224053	29%	↑	0.015
VDBP	gi:18655424	38%	↓	0.020
ApoAI	gi:90109664	49%	↓	0.027

^§A2M, alpha 2 macroglobulin; VDBP, vitamin D binding protein; ApoAI, apolipoprotien AI.^¶The p value was calculated by one way ANOVA with DeCyder 6.5 software. ↑, present in normal and each fibrotic stage but the protein expression in fibrotic stages (F1-F4) is higher than that in normal control (F0); ↓, present in normal and each fibrotic stage but the protein expression in moderate/advanced fibrotic stages (F3/F4) is lower than that in normal control/mild fibrotic stage (F0/F1).

ISSN: 1423-0127