Figure 7
In vivo tumor treatment experiment. C57BL/6 mice were inoculated with 5 × 105/mouse of MOSEC/luc tumor cells. Four days later, MOSEC/luc tumor-bearing mice were treated with a low (2 × 105/mouse) or high (2 × 106/mouse) numbers of irradiated MOSEC-dox(100 μg/ml) tumor cells. As controls, groups of MOSEC/luc tumor-bearing mice were treated with irradiated MOSEC cells (2 × 105/mouse) or left without treatment (naïve). Survival analysis was also performed of the different groups of mice. (A) Representative bioluminescence images of MOSEC/luc tumor-bearing mice treated with the different numbers of doxorubicin-treated MOSEC tumor cells. (B) Line graph illustrating the measured values of luminescent intensity in the different groups of mice. (C) Kaplan-Meier survival analysis of MOSEC/luc tumor-bearing mice treated with low and high numbers of doxorubicin-treated MOSEC cells compared to the control groups.