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Table 1 PD candidate genes.

From: Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons

  Gene Name Accession No. Symbol Screen Position Locus
1 Tetraspanin 6 NM_003270.2 Tspan6 Chung et al. Xq22.1 PARK 12
2 ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) NM_001111112.1 UBE2K Chung et al. 4p14 PARK 5
3 Ribosomal protein L11 NM_000975.2 RPL11 Chung et al. 1p36.1-p35 PARK 6 & 7
4 Ribosomal protein L36a NM_021029.4 RPL36A Chung et al. Xq22.1 PARK 12
5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 NM_003069.3 SMARCA1 Chung et al. Xq25 PARK 12
6 MARCKS-like 1 NM_023009.5 MARCKSL1 Chung et al. 1p35.1 PARK 6
7 GTPase activating protein 24 NM_001025616.2 ARHGAP24 Chung et al. 4q21.23-4q21.3 PARK 4
8 F-box only protein 2 NM_012168.4 FBXO2 Chung et al. 1p36.22 PARK 7
9 T-complex-associated-testis-expressed 1-like NM_006520.2 DYNLT3 Chung et al. Xp21 PARK 12
10 Cyclin I NM_006835.2 CCNI Chung et al. 4q21.1 PARK 4
11 Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 NM_001152.4 SLC25A5 Chung et al. Xq24-q26 PARK 12
12 Pyruvate dehydrogenase E1 alpha 1 NM_000284.2 PDHA1 Greene et al. Xp22.12 PARK 12
13 Ubiquitin carboxy-terminal hydrolase L1 PARK NM_004181.4 UCHL1 Greene et al. 4p14 PARK 5
14 G protein-coupled receptor, family C, group 5, member A NM_003979.3 GPRC5A Grimm et al. 12p13.1 PARK 8
15 Protein tyrosin phosphatase, receptor type, U NM_005704.3 PTPRU Grimm et al. 1p35.3 PARK 6
16 Klech-like 13 (drosophila) NM_001168299.1 KLHL13 Grimm et al. Xq24 PARK 12
17 Dehyrogenase/reductase (SDR family) member 3 NM_004753.4 DHRS3 Grimm et al. 1p36.22-1p36.21 PARK 7
18 NEL-like 2 (chicken) NM_001145107.1 NELL2 Grimm et al. 12q13.11-q13.12 PARK 8
19 Serin (or cysteine) peptidase inhibitor clade B, member 6a NM_004568.4 SERPINB6 Grimm et al. 6q25 PARK 2
20 Peripherin 1 NM_006262.3 PRPH Grimm et al. 12q12-q13 PARK 8
  1. The list of genes, with ISH-detectable expression in midbrain dopaminergic neurons, with cytogenetic locations, falling within PARK loci are shown. Numbers 1,4,5,9,11,12 and 16 are within PARK-12, an orphan PD locus and UCHL1 (13) is a known PD gene.
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Journal of Biomedical Science

ISSN: 1423-0127