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Table 1 PD candidate genes.

From: Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons

 

Gene Name

Accession No.

Symbol

Screen

Position

Locus

1

Tetraspanin 6

NM_003270.2

Tspan6

Chung et al.

Xq22.1

PARK 12

2

ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)

NM_001111112.1

UBE2K

Chung et al.

4p14

PARK 5

3

Ribosomal protein L11

NM_000975.2

RPL11

Chung et al.

1p36.1-p35

PARK 6 & 7

4

Ribosomal protein L36a

NM_021029.4

RPL36A

Chung et al.

Xq22.1

PARK 12

5

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

NM_003069.3

SMARCA1

Chung et al.

Xq25

PARK 12

6

MARCKS-like 1

NM_023009.5

MARCKSL1

Chung et al.

1p35.1

PARK 6

7

GTPase activating protein 24

NM_001025616.2

ARHGAP24

Chung et al.

4q21.23-4q21.3

PARK 4

8

F-box only protein 2

NM_012168.4

FBXO2

Chung et al.

1p36.22

PARK 7

9

T-complex-associated-testis-expressed 1-like

NM_006520.2

DYNLT3

Chung et al.

Xp21

PARK 12

10

Cyclin I

NM_006835.2

CCNI

Chung et al.

4q21.1

PARK 4

11

Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5

NM_001152.4

SLC25A5

Chung et al.

Xq24-q26

PARK 12

12

Pyruvate dehydrogenase E1 alpha 1

NM_000284.2

PDHA1

Greene et al.

Xp22.12

PARK 12

13

Ubiquitin carboxy-terminal hydrolase L1 PARK

NM_004181.4

UCHL1

Greene et al.

4p14

PARK 5

14

G protein-coupled receptor, family C, group 5, member A

NM_003979.3

GPRC5A

Grimm et al.

12p13.1

PARK 8

15

Protein tyrosin phosphatase, receptor type, U

NM_005704.3

PTPRU

Grimm et al.

1p35.3

PARK 6

16

Klech-like 13 (drosophila)

NM_001168299.1

KLHL13

Grimm et al.

Xq24

PARK 12

17

Dehyrogenase/reductase (SDR family) member 3

NM_004753.4

DHRS3

Grimm et al.

1p36.22-1p36.21

PARK 7

18

NEL-like 2 (chicken)

NM_001145107.1

NELL2

Grimm et al.

12q13.11-q13.12

PARK 8

19

Serin (or cysteine) peptidase inhibitor clade B, member 6a

NM_004568.4

SERPINB6

Grimm et al.

6q25

PARK 2

20

Peripherin 1

NM_006262.3

PRPH

Grimm et al.

12q12-q13

PARK 8

  1. The list of genes, with ISH-detectable expression in midbrain dopaminergic neurons, with cytogenetic locations, falling within PARK loci are shown. Numbers 1,4,5,9,11,12 and 16 are within PARK-12, an orphan PD locus and UCHL1 (13) is a known PD gene.