TY - JOUR AU - Birkmayer, W. AU - Hornykiewicz, O. PY - 1998 DA - 1998// TI - The effect of l-3,4-dihydroxyphenylalanine (= DOPA) on akinesia in Parkinsonism JO - Parkinsonism Relat Disord VL - 4 UR - https://doi.org/10.1016/S1353-8020(98)00013-3 DO - 10.1016/S1353-8020(98)00013-3 ID - Birkmayer1998 ER - TY - JOUR AU - Hauser, R. PY - 2009 DA - 2009// TI - Levodopa: Past, present and future JO - Eur Neurol VL - 62 UR - https://doi.org/10.1159/000215875 DO - 10.1159/000215875 ID - Hauser2009 ER - TY - JOUR AU - LeWitt, P. A. PY - 2008 DA - 2008// TI - Levodopa for the treatment of Parkinson's disease JO - N Eng J Med VL - 359 UR - https://doi.org/10.1056/NEJMct0800326 DO - 10.1056/NEJMct0800326 ID - LeWitt2008 ER - TY - JOUR AU - Olanow, C. W. AU - Stern, M. B. AU - Sethi, K. PY - 2009 DA - 2009// TI - The scientific and clinical basis for the treatment of Parkinson's disease JO - Neurology VL - 72 UR - https://doi.org/10.1212/WNL.0b013e3181a1d44c DO - 10.1212/WNL.0b013e3181a1d44c ID - Olanow2009 ER - TY - JOUR AU - Juncos, J. L. PY - 1992 DA - 1992// TI - Levodopa: pharmacology, pharmacokinetics, and pharmacodynamics JO - Neurol Clin VL - 10 ID - Juncos1992 ER - TY - JOUR AU - Nomoto, M. AU - Nishikawa, N. AU - Nagai, M. AU - Yabe, H. AU - Nakatsuka, A. AU - Moritoyo, H. AU - Moritoyo, T. AU - Kubo, M. PY - 2009 DA - 2009// TI - Inter- and intra-individual variation in l-dopa pharmacokinetics in the treatment of Parkinson's disease JO - Parkinsonism Relat Disord VL - 15 UR - https://doi.org/10.1016/S1353-8020(09)70007-0 DO - 10.1016/S1353-8020(09)70007-0 ID - Nomoto2009 ER - TY - JOUR AU - Jenner, P. PY - 2008 DA - 2008// TI - Molecular mechanisms of l-dopa -induced dyskinesia JO - Nat Rev Neurosci VL - 9 UR - https://doi.org/10.1038/nrn2471 DO - 10.1038/nrn2471 ID - Jenner2008 ER - TY - JOUR AU - Abbruzzese, G. PY - 2008 DA - 2008// TI - Optimising levodopa therapy JO - Neurol Sci VL - 29 UR - https://doi.org/10.1007/s10072-008-1051-x DO - 10.1007/s10072-008-1051-x ID - Abbruzzese2008 ER - TY - JOUR AU - Lennernas, H. AU - Nilsson, D. AU - Aquilonius, S. M. AU - Ahrenstedt, O. AU - Knutson, L. AU - Paalzow, L. K. PY - 1993 DA - 1993// TI - The effect of l-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man JO - Br J Clin Pharmacol VL - 35 UR - https://doi.org/10.1111/j.1365-2125.1993.tb05691.x DO - 10.1111/j.1365-2125.1993.tb05691.x ID - Lennernas1993 ER - TY - JOUR AU - Kempster, P. A. AU - Wahlqvist, M. L. PY - 1994 DA - 1994// TI - Dietary factors in the management of Parkinson's Disease JO - Nutr Rev VL - 52 ID - Kempster1994 ER - TY - JOUR AU - Crevoisier, C. AU - Zerr, P. AU - Calvi-Gries, F. AU - Nilsen, T. PY - 2003 DA - 2003// TI - Effects of food on the pharmacokinetics of levodopa in a dual-release formulation JO - Eur J Pharm Biopharm VL - 55 UR - https://doi.org/10.1016/S0939-6411(02)00124-8 DO - 10.1016/S0939-6411(02)00124-8 ID - Crevoisier2003 ER - TY - JOUR AU - Groneberg, D. A. AU - Döring, F. AU - Eynott, P. R. AU - Fischer, A. AU - Daniel, H. PY - 2001 DA - 2001// TI - Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1 JO - Am J Physiol Gastrointest Liver Physiol VL - 281 ID - Groneberg2001 ER - TY - JOUR AU - Brodin, B. AU - Nielsen, C. U. AU - Steffansen, B. AU - Frokjaer, S. PY - 2002 DA - 2002// TI - Transport of peptidomimetic drugs by the intestinal di/tri-peptide transporter, PepT1 JO - Pharmacol Toxicol VL - 90 UR - https://doi.org/10.1034/j.1600-0773.2002.900601.x DO - 10.1034/j.1600-0773.2002.900601.x ID - Brodin2002 ER - TY - JOUR AU - Hironaka, T. AU - Itokawa, S. AU - Ogawara, K. AU - Higaki, K. AU - Kimura, T. PY - 2009 DA - 2009// TI - Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats JO - Pharm Res VL - 26 UR - https://doi.org/10.1007/s11095-008-9703-3 DO - 10.1007/s11095-008-9703-3 ID - Hironaka2009 ER - TY - JOUR AU - Knütter, I. AU - Wollesky, C. AU - Kottra, G. AU - Hahn, M. G. AU - Fischer, W. AU - Zebisch, K. AU - Neubert, R. H. AU - Daniel, H. AU - Brandsch, M. PY - 2008 DA - 2008// TI - Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited JO - J Pharmacol Exp Ther VL - 327 UR - https://doi.org/10.1124/jpet.108.143339 DO - 10.1124/jpet.108.143339 ID - Knütter2008 ER - TY - JOUR AU - Brandsch, M. AU - Knutter, L. AU - Leibach, F. H. PY - 2004 DA - 2004// TI - The intestinal H+/peptide symporter PEPT1: structure-affinity relationships JO - Eur J Pharm Sci VL - 21 UR - https://doi.org/10.1016/S0928-0987(03)00142-8 DO - 10.1016/S0928-0987(03)00142-8 ID - Brandsch2004 ER - TY - JOUR AU - Vig, B. S. AU - Stouch, T. R. AU - Timoszyk, J. K. AU - Quan, Y. AU - Wall, D. A. AU - Smith, R. L. AU - Faria, T. N. PY - 2006 DA - 2006// TI - Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding JO - J Med Chem VL - 49 UR - https://doi.org/10.1021/jm0511029 DO - 10.1021/jm0511029 ID - Vig2006 ER - TY - JOUR AU - Larsen, S. B. AU - Jørgensen, F. S. AU - Olsen, L. PY - 2008 DA - 2008// TI - QSAR models for human H+/peptide symporter, hPEPT1: Affinity prediction using alignment-independent descriptors JO - J Chem Inf Model VL - 48 UR - https://doi.org/10.1021/ci700346y DO - 10.1021/ci700346y ID - Larsen2008 ER - TY - JOUR AU - Brandsh, M. PY - 2009 DA - 2009// TI - Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls JO - Expert Opin Drug Metab Toxicol VL - 5 UR - https://doi.org/10.1517/17425250903042292 DO - 10.1517/17425250903042292 ID - Brandsh2009 ER - TY - JOUR AU - Majumdar, S. AU - Duvvuri, S. AU - Mitra, A. K. PY - 2004 DA - 2004// TI - Membrane transporter/receptor-targeted prodrug design: Strategies for human and veterinary drug development JO - Adv Drug Deliv Rev VL - 56 UR - https://doi.org/10.1016/j.addr.2004.02.006 DO - 10.1016/j.addr.2004.02.006 ID - Majumdar2004 ER - TY - JOUR AU - Wang, H. P. AU - Lu, H. H. AU - Lee, J. S. AU - Cheng, C. Y. AU - Mah, J. R. AU - Hsu, W. L. AU - Yen, C. F. AU - Lin, C. J. AU - Kuo, H. S. PY - 1996 DA - 1996// TI - Intestinal absorption studies on peptide mimetic alpha-methyldopa prodrugs JO - J Pharm Pharmacol VL - 48 UR - https://doi.org/10.1111/j.2042-7158.1996.tb05915.x DO - 10.1111/j.2042-7158.1996.tb05915.x ID - Wang1996 ER - TY - JOUR AU - Wang, H. P. AU - Wang, C. L. PY - 2010 DA - 2010// TI - Biological Transporters as Target for New Drug Design JO - J Exp Clin Med VL - 1 UR - https://doi.org/10.1016/S1878-3317(09)60008-5 DO - 10.1016/S1878-3317(09)60008-5 ID - Wang2010 ER - TY - CHAP AU - Sheikh, M. I. AU - Muller, J. V. ED - Snell, K. ED - Mullock, B. PY - 1987 DA - 1987// TI - Preparation and use of renal and intestinal plasma membrane vesicles for toxicological studies BT - Biochemical Toxicology: A Practical Approach PB - IRL press CY - Oxford ID - Sheikh1987 ER - TY - JOUR AU - Anand, B. S. AU - Patel, J. AU - Mitra, A. K. PY - 2003 DA - 2003// TI - Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2 JO - J Pharmacol Exp Ther VL - 304 UR - https://doi.org/10.1124/jpet.102.044313 DO - 10.1124/jpet.102.044313 ID - Anand2003 ER - TY - JOUR AU - Okano, T. AU - Inui, K. AU - Takano, M. AU - Hori, R. PY - 1986 DA - 1986// TI - H+ gradient-dependent transport of aminocephalosporins in rat intestinal brush-border membrane vesicles JO - Biochem Pharmacol VL - 35 UR - https://doi.org/10.1016/0006-2952(86)90292-3 DO - 10.1016/0006-2952(86)90292-3 ID - Okano1986 ER - TY - JOUR AU - Lu, H. H. AU - Thomas, J. AU - Fleisher, D. PY - 1992 DA - 1992// TI - Influence of d-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs JO - J Pharm Sci VL - 81 UR - https://doi.org/10.1002/jps.2600810105 DO - 10.1002/jps.2600810105 ID - Lu1992 ER - TY - JOUR AU - Hu, M. AU - Subramanian, P. AU - Mosberg, H. I. AU - Amidon, G. L. PY - 1989 DA - 1989// TI - Use of the peptide carrier system to improve the intestinal absorption of l-alpha-methyldopa: Carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of l- alpha-methyldopa JO - Pharm Res VL - 6 UR - https://doi.org/10.1023/A:1015855820488 DO - 10.1023/A:1015855820488 ID - Hu1989 ER - TY - JOUR AU - Amidon, G. L. AU - Sinko, P. J. AU - Fleisher, D. PY - 1988 DA - 1988// TI - Estimating human oral fraction dose absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds JO - Pharm Res VL - 5 UR - https://doi.org/10.1023/A:1015927004752 DO - 10.1023/A:1015927004752 ID - Amidon1988 ER - TY - JOUR AU - Reigelman, S. AU - Collier, P. PY - 1980 DA - 1980// TI - The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time JO - J Pharmacokinet Biopharm VL - 8 UR - https://doi.org/10.1007/BF01059549 DO - 10.1007/BF01059549 ID - Reigelman1980 ER - TY - JOUR AU - Kaplan, S. A. AU - Jack, M. L. AU - Cotler, S. AU - Alexander, K. PY - 1973 DA - 1973// TI - Utilization of area under the curve to elucidate the disposition of an extensively biotransformed drug JO - J Pharmacokinet Pharmacodyn VL - 1 UR - https://doi.org/10.1007/BF01062347 DO - 10.1007/BF01062347 ID - Kaplan1973 ER - TY - BOOK AU - Paxinos, G. AU - Waston, C. PY - 1986 DA - 1986// TI - The Rat Brain in Sterotaxic Coordinates PB - Academic Press CY - New York ID - Paxinos1986 ER - TY - JOUR AU - Hudson, J. L. AU - van Horne, C. G. AU - Stromberg, I. AU - Brock, S. AU - Clayton, J. AU - Masserano, J. AU - Hoffer, B. J. AU - Gerhard, G. A. PY - 1993 DA - 1993// TI - Correlation of apomorphine and amphetamine induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats JO - Brain Res VL - 626 UR - https://doi.org/10.1016/0006-8993(93)90576-9 DO - 10.1016/0006-8993(93)90576-9 ID - Hudson1993 ER - TY - JOUR AU - Iancu, R. AU - Mohapel, P. AU - Brundin, P. AU - Paul, G. PY - 2005 DA - 2005// TI - Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice JO - Behav Brain Res VL - 162 UR - https://doi.org/10.1016/j.bbr.2005.02.023 DO - 10.1016/j.bbr.2005.02.023 ID - Iancu2005 ER - TY - JOUR AU - Beal, M. F. PY - 2001 DA - 2001// TI - Experimental models of Parkinson's disease JO - Nat Rev Neurosci VL - 2 UR - https://doi.org/10.1038/35072550 DO - 10.1038/35072550 ID - Beal2001 ER - TY - JOUR AU - Metz, G. A. AU - Tse, A. AU - Ballermann, M. AU - Smith, L. K. AU - Fouad, K. PY - 2005 DA - 2005// TI - The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis JO - Eur J Neurosci VL - 22 UR - https://doi.org/10.1111/j.1460-9568.2005.04238.x DO - 10.1111/j.1460-9568.2005.04238.x ID - Metz2005 ER - TY - JOUR AU - Lennernäs, H. PY - 2007 DA - 2007// TI - Animal data: The contribution of the Ussing chamber and perfusion system to predicting human oral drug delivery in vivo JO - Adv Drug Deliv Rev VL - 59 UR - https://doi.org/10.1016/j.addr.2007.06.016 DO - 10.1016/j.addr.2007.06.016 ID - Lennernäs2007 ER - TY - JOUR AU - Johnson, D. A. AU - Amidon, G. L. PY - 1988 DA - 1988// TI - Determination of intrinsic membrane transport parameters from perfused intestine experiments: a boundary layer approach to estimating the aqueous and unbiased membrane permeabilities JO - J Theor Biol VL - 131 UR - https://doi.org/10.1016/S0022-5193(88)80123-1 DO - 10.1016/S0022-5193(88)80123-1 ID - Johnson1988 ER -