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Table 2 Pharmacokinetic parameters derived from non-compartmental analysis after i.v. and oral administration of d-phenylglycine-l-dopa and l-dopa in rats (mean ± SD, n = 6).

From: Evidence of d-phenylglycine as delivering tool for improving l-dopa absorption

  d-phenylglycine-l-dopa l-dopa
i.v. Oral i.v. Oral
AUC (mg·min/ml) 62.53 ± 19.68 28.85 ± 8.52 459.81 ± 195.14 27.37 ± 4.60
t1/2(min) 254.10 ± 73.05 142.50 ± 23.71 101.52 ± 27.74 184.80 ± 46.20
Clp (l/kg/min) 0.18 ± 0.06 0.29 ± 0.10 0.02 ± 0.02 0.01 ± 0.00
Vdss (l/kg) 11.01 ± 5.08 35.7 ± 17.1 1.22 ± 0.89 1.22 ± 0.36
tmax(min) 38.30 ± 17.72 25.02 ± 16.10
Fraction of absorption (%) 27.58 ± 4.56 0.87 ± 0.24