Table 2 Pharmacokinetic parameters derived from non-compartmental analysis after i.v. and oral administration of d-phenylglycine-l-dopa and l-dopa in rats (mean ± SD, n = 6).

AUC (mg·min/ml)

62.53 ± 19.68

28.85 ± 8.52

459.81 ± 195.14

27.37 ± 4.60

t_1/2(min)

254.10 ± 73.05

142.50 ± 23.71

101.52 ± 27.74

184.80 ± 46.20

Cl_p (l/kg/min)

0.18 ± 0.06

0.29 ± 0.10

0.02 ± 0.02

0.01 ± 0.00

Vd_ss (l/kg)

11.01 ± 5.08

35.7 ± 17.1

1.22 ± 0.89

1.22 ± 0.36

t_max(min)

–

38.30 ± 17.72

–

25.02 ± 16.10

Fraction of absorption (%)

–

27.58 ± 4.56

–

0.87 ± 0.24