Figure 1

Transcriptional upregulation of HO-1 in RVLM ameliorates failure of central cardiovascular regulation associated with experimental brain stem death. Temporal changes in mean systemic arterial pressure (MSAP), heart rate (HR) or power density of the low-frequency (LF) component of SAP signals in rats that received pretreatment by microinjection bilaterally into RVLM of NRS (1:20) or HO-1 antiserum (1:20); or aCSF, scrambled (SC; 50 pmol), sense (S; 50 pmol) or antisense (AS; 50 pmol) ho-1 oligonucleotide (right column), 1 h or 24 h before local application (at arrow) of aCSF or Mev (10 nmol) to the bilateral RVLM. Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus NRS+aCSF or aCSF+aCSF group, and ⁺P < 0.05 versus NRS+Mev or aCSF+Mev group at corresponding time-points in the Scheffé multiple-range test.