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Figure 4 | Journal of Biomedical Science

Figure 4

From: Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla

Figure 4

Lack of effect of HO-2 in RVLM on failure of central cardiovascular regulation associated with experimental brain stem death. Temporal changes in MSAP, HR or power density of the LF component of SAP signals in rats that received pretreatment by microinjection bilaterally into RVLM of normal rabbit serum (NRS; 1:20) or HO-2 antiserum (1:20); or aCSF, scrambled (SC; 50 pmol), sense (S; 50 pmol) or antisense (AS; 50 pmol) ho-2 oligonucleotide (right column), 1 h or 24 h before local application (at arrow) of aCSF or Mev (10 nmol) to the bilateral RVLM. Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus NRS+aCSF or aCSF+aCSF group, and +P < 0.05 versus NRS+Mev or aCSF+Mev group at corresponding time-points in the Scheffé multiple-range test.

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