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Table 3 Metabolic enzymes identified in BxPC-3 cells

From: Membrane proteomic analysis of pancreatic cancer cells

Protein name

Accession #

Unique peptides

Total peptides

Mr (KDa)

PI

Biological process

2-oxoglutarate dehydrogenase E1 component, mitochondrial

ODO1_HUMAN

4

4

115.9

6.39

Glycolysis

3-ketoacyl-CoA thiolase, mitochondrial

THIM_HUMAN

2

4

41.9

8.32

Fatty acid metabolism Lipid metabolism

78 kDa glucose-regulated protein

GRP78_HUMAN

31

91

72.3

5.07

ER-associated protein catabolic process ER unfolded protein response ER regulation of protein folding

Adenylate kinase 2, mitochondrial

KAD2_HUMAN

4

7

26.5

7.67

Nucleotide/nucleic acid metabolic process

ADP/ATP translocase 2

ADT2_HUMAN

2

5

32.9

9.76

Transmembrane transporter activity

Alpha-aminoadipic semialdehyde dehydrogenase

AL7A1_HUMAN

2

2

55.3

6.44

Cellular aldehyde metabolic process; oxidation reduction

Alpha-enolase

ENOA_HUMAN

3

5

47.1

7.01

Glycolysis

Annexin A1

ANXA1_HUMAN

4

5

38.7

6.57

Anti-apoptosis; Exocytosis; Lipid metabolic process

Aspartate aminotransferase, mitochondrial precursor

AATM_HUMAN

2

7

47.4

9.14

Lipid transport

ATP synthase subunit alpha, mitochondrial

ATPA_HUMAN

3

6

59.7

9.16

ATP synthesis

ATP synthase subunit beta, mitochondrial

ATPB_HUMAN

4

13

56.5

5.26

ATP synthesis

ATP synthase subunit d, mitochondrial

ATP5H_HUMAN

2

4

18.5

5.21

ATP synthesis; Ion transport

ATP synthase subunit gamma, mitochondrial

ATPG_HUMAN

2

3

33

9.23

ATP synthesis; Proton transport

ATP synthase subunit O, mitochondrial

ATPO_HUMAN

2

3

23.3

9.97

ATP synthesis; Ion transport ATP catabolic process

Calcium-binding mitochondrial carrier protein Aralar2

CMC2_HUMAN

2

4

74.1

7.14

Mitochondrial aspartate and glutamate carrier

Citrate synthase, mitochondrial;

CISY_HUMAN

3

5

51.7

8.45

Tricarboxylic acid cycle

Cytochrome b-c1 complex subunit 1, mitochondrial

QCR1_HUMAN

3

5

52.6

5.94

Electron transport

Cytochrome b-c1 complex subunit 2, mitochondrial

QCR2_HUMAN

2

2

48.4

8.74

Aerobic respiration; Electron transport chain; Oxidative phosphorylation

Cytochrome c oxidase subunit 2

COX2_HUMAN

2

4

25.5

4.67

Electron transport chain

Cytochrome c oxidase subunit 5B, mitochondrial precursor

COX5B_HUMAN

2

2

13.7

9.07

Respiratory gaseous exchange

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

ECH1_HUMAN

2

6

35.8

8.16

Fatty acid metabolism; Lipid metabolism

Delta-1-pyrroline-5-carboxylate synthetase

P5CS_HUMAN

2

3

87.2

6.66

Amino-acid biosynthesis; Proline biosynthesis

Dihydrolipoyl dehydrogenase, mitochondrial

DLDH_HUMAN

5

13

54.1

7.95

Cell redox homeostasis

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

ODO2_HUMAN

3

6

48.6

9.01

Tricarboxylic acid cycle

Electron transfer flavoprotein subunit alpha, mitochondrial

ETFA_HUMAN

3

7

35.1

8.62

Electron transport

Electron transfer flavoprotein subunit beta

ETFB_HUMAN

2

3

27.8

8.25

Electron transport

Endoplasmin

ENPL_HUMAN

16

31

92.4

4.76

ER-associated protein catabolic process; protein folding/transport; response to hypoxia

Enoyl-CoA hydratase, mitochondrial

ECHM_HUMAN

3

12

31.4

8.34

Fatty acid metabolism; Lipid metabolism

ERO1-like protein alpha precursor

ERO1A_HUMAN

2

3

54.4

5.48

Electron transport

Glucosidase 2 subunit beta

GLU2B_HUMAN

2

5

59.4

4.33

ER protein kinase cascade

Glutamate dehydrogenase 1, mitochondrial

DHE3_HUMAN

2

2

61.4

7.66

Glutamate metabolism

Glyceraldehyde-3-phosphate dehydrogenase

G3P_HUMAN

2

2

36

8.57

Glycolysis

Glycerol-3-phosphate dehydrogenase, mitochondrial

GPDM_HUMAN

2

4

80.8

7.23

Glycolysis

Heme oxygenase 2

HMOX2_HUMAN

2

4

36

5.31

Heme oxidation; Oxidation reduction; Response to hypoxia

Hexokinase-1

HXK1_HUMAN

2

3

102.4

6.36

Glycolysis

L-2-hydroxyglutarate dehydrogenase, mitochondrial

L2HDH_HUMAN

2

2

50.3

8.57

Cellular protein metabolic process; Oxidation reduction

Lon protease homolog, mitochondrial

LONM_HUMAN

2

2

106.4

6.01

Required for intramitochondrial proteolysis

Long-chain-fatty-acid--CoA ligase 3

ACSL3_HUMAN

2

3

80.4

8.65

Fatty acid metabolism; Lipid metabolism

Long-chain-fatty-acid--CoA ligase 4

ACSL4_HUMAN

2

3

79.1

8.66

Fatty acid metabolism; Lipid metabolism

Malate dehydrogenase, mitochondrial

MDHM_HUMAN

3

4

35.5

8.92

TCA glycolysis

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

ACADM_HUMAN|

2

3

46.6

8.61

Fatty acid metabolism; Lipid metabolism

Methylenetetrahydrofolate reductase

MTHR_HUMAN

2

2

74.5

5.22

Methionine metabolic process; Oxidation reduction

Mitochondrial 2-oxoglutarate/malate carrier protein

M2OM_HUMAN

2

2

34

9.92

Transport

Mitochondrial import receptor subunit TOM40 homolog

TOM40_HUMAN

3

3

37.9

6.79

Ion transport; Protein transport

Neutral alpha-glucosidase AB

GANAB_HUMAN

7

10

106.8

5.74

Carbohydrate metabolic process

Neutral cholesterol ester hydrolase 1

ADCL1_HUMAN

2

4

45.8

6.76

Lipid degradation

Ornithine aminotransferase, mitochondrial precursor

OAT_HUMAN

4

6

48.5

6.57

Mitochondrial matrix protein binding

Phosphoenolpyruvate carboxykinase, mitochondrial

PPCKM_HUMAN

2

3

70.6

7.56

Gluconeogenesis

Protein disulfide-isomerase

PDIA1_HUMAN

8

14

57.1

4.76

Cell redox homeostasis

Protein disulfide-isomerase A3

PDIA3_HUMAN

16

25

56.7

5.98

Cell redox homeostasis

Protein disulfide-isomerase A4

PDIA4_HUMAN

7

11

72.9

4.96

Cell redox homeostasis; Protein secretion

Protein disulfide-isomerase A6

PDIA6_HUMAN

2

4

48.1

4.95

Cell redox homeostasis; Protein folding

Pyruvate kinase isozymes M1/M2

KPYM_HUMAN

5

7

57.9

7.96

Glycolysis; Programmed cell death

Serine hydroxymethyltransferase, mitochondrial precursor

GLYM_HUMAN

2

4

56

8.76

L-serine metabolic process; Glycine metabolic process; One-carbon metabolic process

Sterol regulatory element-binding protein 2

SRBP2_HUMAN

2

2

123.6

8.72

Cholesterol metabolism; Lipid metabolism; Steroid metabolism;

Succinate dehydrogenase flavoprotein subunit, mitochondrial

DHSA_HUMAN

3

10

72.6

7.06

Electron transport; Tricarboxylic acid cycle

Succinyl-CoA:3-ketoacid-coenzyme A transferase 1

SCOT_HUMAN

2

5

56.1

7.13

Ketone body catabolic process

Sulfide:quinone oxidoreductase, mitochondrial

SQRD_HUMAN

6

9

49.9

9.18

Oxidation reduction

Superoxide dismutase [Mn], mitochondrial

SODM_HUMAN

2

5

24.7

8.35

Elimination of radicals

Transmembrane emp24 domain-containing protein 10

TMEDA_HUMAN

2

3

25

6.98

ER-Golgi protein transport

Trifunctional enzyme subunit alpha, mitochondrial

ECHA_HUMAN

4

7

82.9

9.16

Fatty acid metabolism; Lipid metabolism

Trifunctional enzyme subunit beta, mitochondrial

ECHB_HUMAN

2

4

51.3

9.45

Fatty acid metabolism